Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb;15(1):5-14.
doi: 10.1007/s12265-021-10138-4. Epub 2021 Aug 2.

Plasmatic PCSK9 Levels Are Associated with Very Fast Progression of Asymptomatic Degenerative Aortic Stenosis

Natalia Mateos  1 , Miquel Gómez  1   2   3 , Arianna Homar  1 , Anna Garcia-Elias  2   4 , Laia Yáñez  5 , Marta Tajes  6 , Lluís Molina  7 , Mireia Ble  7 , Mercè Cladellas  7 , Cristina Roqueta  8 , Begoña Benito  9   10   11   12   13
Affiliations

Plasmatic PCSK9 Levels Are Associated with Very Fast Progression of Asymptomatic Degenerative Aortic Stenosis

Natalia Mateos et al. J Cardiovasc Transl Res. 2022 Feb.

Abstract

The aim of this work was to study the association of potential biomarkers with fast aortic stenosis (AS) progression. Patients with moderate-to-severe AS were classified as very fast progressors (VFP) if exhibited an annualized change in peak velocity (aΔVmax) ≥0.45m/s/year and/or in aortic valve area (aΔAVA) ≥-0.2cm2/year. Respective cut-off values of ≥0.3m/s/year and ≥-0.1cm2/year defined fast progressors (FP), whereas the remaining patients were non-fast progressors (non-FP). Baseline markers of lipid metabolism, inflammation, and cardiac overload were determined. Two hundred and nine patients (97 non-FP, 38 FP, and 74 VFP) were included. PCSK9 levels were significantly associated with VFP (OR 1.014 [95%CI 1.005-1.024], for every 10 ng/mL), as were active smoking (OR 3.48) and body mass index (BMI, OR 1.09), with an AUC of 0.704 for the model. PCSK9 levels, active smoking, and BMI were associated with very fast AS progression in our series, suggesting that inflammation and calcification participate in disease progression.

Keywords: Aortic stenosis; Biomarkers; Body mass index; Disease progression; PCSK9; Smoking.

PubMed Disclaimer

References

    1. Otto, C. M., & Prendergast, B. (2014). Aortic-valve stenosis — From patients at risk to severe valve obstruction. The New England Journal of Medicine, 371, 744–756. - DOI
    1. Iung, B., & Vahanian, A. (2011). Epidemiology of valvular heart disease in the adult. Nature Reviews. Cardiology, 8, 162–172. - DOI
    1. Généreux, P., Stone, G. W., O’Gara, P. T., Marquis-Gravel, G., Redfors, B., Giustino, G., Pibarot, P., Bax, J. J., Bonow, R. O., & Leon, M. B. (2016). Natural history, diagnostic approaches, and therapeutic strategies for patients with asymptomatic severe aortic stenosis. Journal of the American College of Cardiology, 67, 2263–2288. - DOI
    1. Baumgartner, H., Falk, V., Bax, J. J., De Bonis, M., Hamm, C., Holm, P. J., Iung, B., Lancellotti, P., Lansac, E., Rodriguez Muñoz, D., Rosenhek, R., Sjögren, J., Tornos Mas, P., Vahanian, A., Walther, T., Wendler, O., Windecker, S., & Zamorano, J. L. (2017). Document. 2017 ESC/EACTS Guidelines on the management of valvular heart disease. European Heart Journal, 38, 2739–2791. - DOI
    1. Taniguchi, T., Morimoto, T., Shiomi, H., Ando, K., Kanamori, N., Murata, K., Kitai, T., Kawase, Y., Izumi, C., Miyake, M., Mitsuoka, H., Kato, M., Hirano, Y., Matsuda, S., Nagao, K., Inada, T., Murakami, T., Takeuchi, Y., Yamane, K., Toyofuku, M., Ishii, M., Minamino-Muta, E., Kato, T., Inoko, M., Ikeda, T., Komasa, A., Ishii, K., Hotta, K., Higashitani, N., Kato, Y., Inuzuka, Y., Maeda, C., Jinnai, T., Morikami, Y., Sakata, R., & Kimura, T. (2015). Initial Surgical Versus Conservative Strategies in Patients with Asymptomatic Severe Aortic Stenosis. Journal of the American College of Cardiology, 66, 2827–2838. - DOI

Publication types

LinkOut - more resources