Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond

Sarah N Hilmer^{1

2}, Mirko Petrovic^{1

3}, David G Le Couteur^{1

4}, Janice B Schwartz^{1

5}, Petra Thuermann^{1

6}

Affiliations

¹ Geriatric Subcommittee of the Clinical Division, IUPHAR (International Union of Basic and Clinical Pharmacology), Kansas, USA.
² Kolling Institute, Royal North Shore Hospital and University of Sydney, St Leonards, NSW, Australia.
³ Department of Geriatrics, Ghent University Hospital and Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
⁴ Centre for Education and Research on Ageing, Concord Hospital and University of Sydney, Concord, NSW, Australia.
⁵ Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA.
⁶ HELIOS University Clinic Wuppertal, Philipp Klee-Institute for Clinical Pharmacology, University of Witten/Herdecke, Witten, Germany.

Sarah N Hilmer et al. Br J Clin Pharmacol. 2021 Sep.

. 2021 Sep;87(9):3459-3461.

doi: 10.1111/bcp.14967. Epub 2021 Aug 2.

Sarah N Hilmer^{1

2}, Mirko Petrovic^{1

3}, David G Le Couteur^{1

4}, Janice B Schwartz^{1

5}, Petra Thuermann^{1

6}

¹ Geriatric Subcommittee of the Clinical Division, IUPHAR (International Union of Basic and Clinical Pharmacology), Kansas, USA.
² Kolling Institute, Royal North Shore Hospital and University of Sydney, St Leonards, NSW, Australia.
³ Department of Geriatrics, Ghent University Hospital and Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
⁴ Centre for Education and Research on Ageing, Concord Hospital and University of Sydney, Concord, NSW, Australia.
⁵ Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, California, USA.
⁶ HELIOS University Clinic Wuppertal, Philipp Klee-Institute for Clinical Pharmacology, University of Witten/Herdecke, Witten, Germany.

No abstract available

Conflict of interest statement

The authors have no conflicts of interest relevant to this manuscript.

1. Hilmer SN, Petrovic M, Le Couteur DG, Schwartz JB, Thuermann P.Principles of evaluation and use of COVID‐19 vaccines in older adults. Geriatric Subcommittee of the Clinical Division of IUPHAR (International Union of Basic and Clinical Pharmacology); 2021. https://iuphar.org/wp-content/uploads/2021/02/Vaccine-evaluation-for-old.... Accessed May 17, 2021.
1. Promislow DEL. A geroscience perspective on COVID‐19 mortality. J Gerontol A Biol Sci Med Sci. 2020;75(9):e30‐e33. - PMC - PubMed
1. Cosco TD, Best J, Davis D, et al. What is the relationship between validated frailty scores and mortality for adults with COVID‐19 in acute hospital care? A systematic review. Age Ageing. 2021;50(3):608‐616. - PMC - PubMed
1. Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE. Animal models of frailty: current applications in clinical research. Clin Interv Aging. 2016;11:1519‐1529. - PMC - PubMed
1. Johansen MD, Irving A, Montagutelli X, et al. Animal and translational models of SARS‐CoV‐2 infection and COVID‐19. Mucosal Immunol. 2020;13(6):877‐891. - PMC - PubMed