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Review
. 2022 Aug;69(4):1633-1645.
doi: 10.1002/bab.2233. Epub 2021 Aug 22.

Caspase-3: Structure, function, and biotechnological aspects

Marzieh Asadi  1 , Saeed Taghizadeh  1 , Elina Kaviani  1 , Omid Vakili  2 , Mortaza Taheri-Anganeh  1 , Mahshid Tahamtan  3 , Amir Savardashtaki  1
Affiliations
Review

Caspase-3: Structure, function, and biotechnological aspects

Marzieh Asadi et al. Biotechnol Appl Biochem. 2022 Aug.

Abstract

Caspase-3, a cysteine-aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until it is cleaved by initiator caspases during apoptotic flux. Since caspase-3 has represented valuable capabilities in the field of medical research, biotechnological aspects of this enzyme, including the production of recombinant type, protein engineering, and designing delivery systems, have been considered as emerging therapeutic strategies in treating the apoptosis-related disorders. To date, several advances have been made in the therapeutic use of caspase-3 in the management of some diseases such as cancers, heart failure, and neurodegenerative disorders. In the current review, we intend to discuss the caspase-3's structure, functions, therapeutic applications, as well as its molecular cloning, protein engineering, and relevant delivery systems.

Keywords: apoptosis; biotechnology; caspase-3; diseases; therapeutics.

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References

REFERENCES

    1. Cade CE, Clark AC. Caspases-Key players in apoptosis. Proteases in Apoptosis: Pathways, Protocols and Translational Advances: Springer; 2015, p. 31-51.
    1. Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V. Role of apoptosis in disease. Aging (Albany NY) 2012;4(5):330.
    1. Shalini S, Dorstyn L, Dawar S, KS Old, new and emerging functions of caspases. Cell Death Differ 2015;22(4):526.
    1. D'amelio M, Cavallucci V, Cecconi F. Neuronal caspase-3 signaling: not only cell death. Cell Death Differ 2010;17(7):1104.
    1. Kudelova J, Fleischmannova J, Adamova E, Matalova E. Pharmacological caspase inhibitors: research towards therapeutic perspectives. J Physiol Pharmacol 2015;66(4):473-82.

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