Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium

Kristin A Shimano¹, Anupama Narla², Melissa J Rose³, Nicholas J Gloude⁴, Steven W Allen⁵, Katie Bergstrom⁶, Larisa Broglie⁷, Beth A Carella⁸, Paul Castillo⁹, Jill L O de Jong¹⁰, Yigal Dror¹¹, Amy E Geddis⁶, James N Huang¹, Bonnie W Lau¹², Catherine McGuinn¹³, Taizo A Nakano¹⁴, Kathleen Overholt¹⁵, Jennifer A Rothman¹⁶, Anjali Sharathkumar¹⁷, Evan Shereck¹⁸, Adrianna Vlachos¹⁹, Timothy S Olson²⁰, Alison A Bertuch²¹, Marcin W Wlodarski²², Akiko Shimamura²³, Jessica Boklan²⁴

Affiliations

¹ Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, San Francisco, California, USA.
² Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
³ Division of Hematology, Oncology, and Bone Marrow Transplant, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
⁴ Department of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
⁵ Pediatric Hematology/Oncology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
⁶ Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington, USA.
⁷ Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁸ Department of Pediatrics, Kaiser Permanente, Washington, District of Columbia, USA.
⁹ Division of Pediatric Hematology Oncology, UF Health Shands Children's Hospital, Gainesville, Florida, USA.
¹⁰ Section of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.
¹¹ Marrow Failure and Myelodysplasia Program, Division of Hematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
¹² Pediatric Hematology-Oncology, Dartmouth-Hitchcock, Lebanon, New Hampshire, USA.
¹³ Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA.
¹⁴ Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
¹⁵ Pediatric Hematology and Oncology, Riley Hospital for Children at Indiana University, Indianapolis, Indiana, USA.
¹⁶ Division of Pediatric Hematology and Oncology, Duke University Medical Center, Durham, North Carolina, USA.
¹⁷ Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
¹⁸ Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA.
¹⁹ Hematology, Oncology and Cellular Therapy, Cohen Children's Medical Center, New Hyde Park, New York, USA.
²⁰ Cell Therapy and Transplant Section, Division of Oncology and Bone Marrow Failure, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²¹ Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
²² Department of Hematology, St. Jude Children's Hospital, Memphis, Tennessee, USA.
²³ Cancer and Blood Disorders Center, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.
²⁴ Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.

PMID: 34342889
DOI: 10.1002/ajh.26310

Free article

Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium

Kristin A Shimano et al. Am J Hematol. 2021.

Free article

. 2021 Nov 1;96(11):1491-1504.

doi: 10.1002/ajh.26310. Epub 2021 Aug 20.

Authors

Affiliations

¹ Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, San Francisco, California, USA.
² Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
³ Division of Hematology, Oncology, and Bone Marrow Transplant, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
⁴ Department of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA.
⁵ Pediatric Hematology/Oncology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
⁶ Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington, USA.
⁷ Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁸ Department of Pediatrics, Kaiser Permanente, Washington, District of Columbia, USA.
⁹ Division of Pediatric Hematology Oncology, UF Health Shands Children's Hospital, Gainesville, Florida, USA.
¹⁰ Section of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.
¹¹ Marrow Failure and Myelodysplasia Program, Division of Hematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
¹² Pediatric Hematology-Oncology, Dartmouth-Hitchcock, Lebanon, New Hampshire, USA.
¹³ Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA.
¹⁴ Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
¹⁵ Pediatric Hematology and Oncology, Riley Hospital for Children at Indiana University, Indianapolis, Indiana, USA.
¹⁶ Division of Pediatric Hematology and Oncology, Duke University Medical Center, Durham, North Carolina, USA.
¹⁷ Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
¹⁸ Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA.
¹⁹ Hematology, Oncology and Cellular Therapy, Cohen Children's Medical Center, New Hyde Park, New York, USA.
²⁰ Cell Therapy and Transplant Section, Division of Oncology and Bone Marrow Failure, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
²¹ Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
²² Department of Hematology, St. Jude Children's Hospital, Memphis, Tennessee, USA.
²³ Cancer and Blood Disorders Center, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.
²⁴ Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.

PMID: 34342889
DOI: 10.1002/ajh.26310

Abstract

The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist-oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in North America with interest and expertise in aplastic anemia, inherited bone marrow failure syndromes, and myelodysplastic syndromes. The NAPAAC Bone Marrow Failure Diagnosis and Care Guidelines Working Group was established with the charge of harmonizing the approach to the diagnostic workup of aplastic anemia in an effort to standardize best practices in the field. This document outlines the rationale for initial evaluations in pediatric patients presenting with signs and symptoms concerning for severe aplastic anemia.

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References

REFERENCES

1. Young NS, Kaufman DW. The epidemiology of acquired aplastic anemia. Haematologica. 2008;93(4):489-492.
1. Dufour C, Veys P, Carraro E, et al. Similar outcome of upfront-unrelated and matched sibling stem cell transplantation in idiopathic paediatric aplastic anaemia. A study on behalf of the UKPaediatric BMT working party, Paediatric diseases working party and severe aplastic Anaemia working party of EBMT. Br J Haematol. 2015;171(4):585-594.
1. Rogers ZR, Nakano TA, Olson TS, et al. Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study. Haematologica. 2019;104(10):1974-1983.
1. Rovo A, Tichelli A, Dufour C, Saa-Wp E. Diagnosis of acquired aplastic anemia. Bone Marrow Transplant. 2013;48(2):162-167.
1. Camitta BM, Rappeport JM, Parkman R, Nathan DG. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood. 1975;45(3):355-363.

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Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium

Affiliations

Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium

Authors

Affiliations

Abstract

References

REFERENCES

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical