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Review
. 2021 May 27:26:33.
doi: 10.4103/jrms.JRMS_869_20. eCollection 2021.

The associations of low birth weight with primary hypertension in later life: A systematic review and meta-analysis

Mohammad Reza Sabri  1 , Danial Habibi  2 , Davood Ramezaninezhad  3 , Roghaieh Ghazavi  4 , Alaleh Gheissari  5 , Noushin Mohammadifard  6 , Marjan Mansourian  2 , Nizal Sarrafzadegan  7
Affiliations
Review

The associations of low birth weight with primary hypertension in later life: A systematic review and meta-analysis

Mohammad Reza Sabri et al. J Res Med Sci. .

Abstract

Background: The purpose of this study was to evaluate of the study the role of LBW on EH in children and by studying the existing published literature.

Materials and methods: A comprehensive literature search for original studies was conducted in Clarivate Analytics Web of Science, PubMed, Scopus, and Embase until July 2019. The search used all of the main keywords and its synonyms include essential hypertension, primary hypertension, essential arterial hypertension, idiopathic hypertension, spontaneous hypertension; child, childhood, children, pediatric, pediatrics, infant, infancy, newborn, neonatal, adolescence, teenagers; and BW, newborn weight, neonatal weight, BW.

Results: Twelve articles were eligible for the final evaluation. Due to the difference among studies in the report, studies were divided into two-part. The first part, articles were reported in the LBW and NBW groups (interested outcome were SBP and DBP), and the second part was composed as the EH and NR groups (interested outcome were LBW and NBW). In the first part, SMD for SBP was -1.09 with 95% CI (-1.91,-0.26), and was statistically significant (Z=2.58, P=0.010). As well, SMD for DBP was -0.68 with 95% CI (-1.32,-0.05) statistically significant (Z=2.10, P=0.036). In the second part, SMD for SBP was 0.77 with 95% CI (-0.85, 2.39), and was statistically significant (Z=0.93, P=0.352). Subgroup analysis was performed on the pre-term and full- term babies. SMD for SBP was -0.08 with 95% CI (-0.51, 0.35) in the pre-term, and the full-term was -2.07 with 95% CI (-3.47, -0.67). As well, SMD for DBP was -0.02 with 95% CI (-0.20, 0.17) in the preterm, and the term was -1.35 with 95% CI (-1.57, -1.13).

Conclusion: Although findings of the correlation between BW and EHTN have conflicted. To our knowledge, this is the first report that attempts to a conclusion.

Keywords: Full-term; low birth weight; primary hypertension; term.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the study selection process
Figure 2
Figure 2
Forest plot of mean difference of systolic blood pressure (normal birth weight − low birth weight)
Figure 3
Figure 3
Forest plot of mean difference of diastolic blood pressure (normal birth weight − low birth weight)
Figure 4
Figure 4
Forest plot of mean difference of birth weight (normal − essential hypertension)
Figure 5
Figure 5
Forest plot for the subgroup analysis according to systolic blood pressure
Figure 6
Figure 6
Forest plot for the subgroup analysis according to diastolic blood pressure
See this image and copyright information in PMC

References

    1. Mohammadi-Dolatabadi A, Vakhshoori M, Eghbali-Babadi M, Heidarpour M, Shafie D, Garakyaraghi M, et al. Comparison of multiple blood pressure frequency methods with optimum blood pressure measurement among Iranian individuals. J Res Med Sci. 2020;25:40. - PMC - PubMed
    1. Sabri M, Gheissari A, Mansourian M, Mohammadifard N, Sarrafzadegan N. Essential hypertension in children, a growing worldwide problem. J Res Med Sci. 2019;24:109. - PMC - PubMed
    1. Edvardsson VO, Steinthorsdottir SD, Eliasdottir SB, Indridason OS, Palsson R. Birth weight and childhood blood pressure. Curr Hypertens Rep. 2012;14:596–602. - PubMed
    1. Zhou Y, Qian Z, Vaughn MG, Boutwell BB, Yang M, Zeng XW, et al. Epidemiology of elevated blood pressure and associated risk factors in Chinese children: The SNEC study. J Hum Hypertens. 2016;30:231–6. - PubMed
    1. Raghuraman RP, Duffy D, Carroll VA, Manyonda I, Antonios TF. Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: A pilot study. J Hum Hypertens. 2020;34:1–8. - PMC - PubMed