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. 2021 Jan-Dec:28:10732748211033746.
doi: 10.1177/10732748211033746.

Diagnostic Value of Inflammatory Factors in Patients with Gallbladder Cancer, Dysplasia, and Cholecystitis

Sirin Kucuk  1 , Soycan Mızrak  2
Affiliations

Diagnostic Value of Inflammatory Factors in Patients with Gallbladder Cancer, Dysplasia, and Cholecystitis

Sirin Kucuk et al. Cancer Control. 2021 Jan-Dec.

Abstract

Background: Involving pre-sampled patients with cholecystitis, dysplasia, and adenocarcinoma, the present study aimed to compare the neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) ratios, and plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) values and to determine their prognostic importance.

Methods: The present study involved 187 cholecystectomy specimens that were diagnosed as cholecystitis, dysplasia, and adenocarcinoma. Preoperative neutrophil, monocyte, lymphocyte, and platelet counts, NLR, MLR, and PLR ratios, and PCT, MPV, and PDW levels of the same patient groups were retrospectively recorded.

Results: In the present study, the cut-off values for dysplasia of NLR, PLR, and MLR were found as 1.61, 81.45, and .19, whereas those for cancer of NLR, PLR, and MLR were 2.65, 182.69, and .35, respectively. The NLR, PLR, and MLR values of the chronic cholecystitis and chronic calculous cholecystitis groups were statistically significantly lower than those of the chronic active calculous cholecystitis group (P < .01). The NLR and MLR values of the non-cancer and non-dysplasia groups were statistically lower than those of the cancer and dysplasia groups (P < .05).

Conclusion: According to the results of the present study, using additional imaging methods, acute-phase cholecystitis can be distinguished using preoperative neutrophil and monocyte counts, and NLR, PLR, and MLR cut-off values can be used to distinguish dysplasia, which is the antecedent of gallbladder cancer. It is thought that this might provide patients with an advantage in terms of early treatment and survival.

Keywords: gallbladder pathologies; hemogram parameters; inflammatory response; monocyte/lymphocyte; neutrophil/lymphocyte; platelet/lymphocyte.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.pt

Figures

Figure 1.
Figure 1.
ROC curve of NLR parameter in dysplasia. NLR, neutrophil to lymphocyte ratio; ROC, receiver operating characteristics.
Figure 2.
Figure 2.
ROC curve of MLR parameter in dysplasia. MLR, monocyte/lymphocyte; ROC, receiver operating characteristics.
Figure 3.
Figure 3.
ROC curve of PLR parameter in dysplasia. PLR, platelet to lymphocyte ratio; ROC, receiver operating characteristics.
Figure 4.
Figure 4.
ROC curve of NLR parameter in cancer. NLR, neutrophil to lymphocyte ratio; ROC, receiver operating characteristics.
Figure 5.
Figure 5.
ROC curve of MLR parameter in cancer. MLR, monocyte/lymphocyte; ROC, receiver operating characteristics.
Figure 6.
Figure 6.
ROC curve of PLR parameter in cancer. PLR, platelet to lymphocyte ratio; ROC, receiver operating characteristics.
See this image and copyright information in PMC

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