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Comment
. 2021 Aug 4;21(1):281.
doi: 10.1186/s12905-021-01436-9.

Breast conserving surgery using oxidized regenerated cellulose as filling biomaterial: recommendations to improve clinical outcomes

Gianluca Franceschini  1   2
Affiliations
Comment

Breast conserving surgery using oxidized regenerated cellulose as filling biomaterial: recommendations to improve clinical outcomes

Gianluca Franceschini. BMC Womens Health. .

Abstract

Oxidized regenerated cellulose is considered an optimal local hemostatic agent thanks to its favorable biocompatibility, absorption characteristics and ease-of-use. Recently, oxidized regenerated cellulose has also been used as a filler in breast conserving surgery with a reconstructive purpose in order to repair partial breast defects and improve aesthetic outcomes. However, some postoperative problems due to its use, such as allergic reactions, seroma, foreign-body reaction and misdiagnosis during the follow-up of breast cancer patients, have been shown. These possible surgical complications can undermine clinical outcomes and lead to delay the beginning of oncological treatments with a negative impact on patient quality of life and survival. An adequate surgical expertise and the compliance with some specific recommendations are crucial in order to minimize postoperative issues and optimise aesthetic outcomes.

Keywords: Aesthetic results; Breast cancer; Breast conserving surgery; Hemostatic materials; Oxidized regenerated cellulose; Postoperative complications.

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Conflict of interest statement

Gianluca Franceschini is a member of the editorial board for the BMC Women’s Health journal.

Figures

Fig. 1
Fig. 1
Principal recommendations to prevent postoperative complications and optimise aesthetic outcomes using ORC in breast conserving surgery (ORC oxidized regenerated cellulose, QUORC QUadrantectomy with oxidized regenerated cellulose)
See this image and copyright information in PMC

Comment on

References

    1. Li JJ, Yang Y, Wan Q, Li H, Long QM, Zhang PR. Clinical observation of the regeneration process of defects after breast cancer resection. BMC Womens Health. 2021;21(1):99. doi: 10.1186/s12905-021-01219-2. - DOI - PMC - PubMed
    1. Franceschini G. Internal surgical use of biodegradable carbohydrate polymers. Warning for a conscious and proper use of oxidized regenerated cellulose. Carbohydr Polym. 2019;216:213–216. doi: 10.1016/j.carbpol.2019.04.036. - DOI - PubMed
    1. Piozzi GN, Reitano E, Panizzo V, Rubino B, Bona D, Tringali D, Micheletto G. Practical suggestions for prevention of complications arising from oxidized cellulose retention: a case report and review of the literature. Am J Case Rep. 2018;11(19):812–819. doi: 10.12659/AJCR.910060. - DOI - PMC - PubMed
    1. Franceschini G, Visconti G, Sanchez AM, Di Leone A, Salgarello M, Masetti R. Oxidized regenerated cellulose in breast surgery: experimental model. J Surg Res. 2015;198(1):237–244. doi: 10.1016/j.jss.2015.05.012. - DOI - PubMed
    1. Franceschini G, Visconti G, Terribile D, Fabbri C, Magno S, Di Leone A, Salgarello M, Masetti R. The role of oxidized regenerate cellulose to prevent cosmetic defects in oncoplastic breast surgery. Eur Rev Med Pharmacol Sci. 2012;16(7):966–971. - PubMed