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. 2016 Feb-Mar:9783:97830U.
doi: 10.1117/12.2216838. Epub 2016 Mar 22.

C-arm cone beam CT perfusion imaging using the SMART-RECON algorithm to improve temporal sampling density and temporal resolution

Yinsheng Li  1 , Kai Niu  1 , Ke Li  1   2 , Sebastian Schafer  3 , Kevin Royalty  3 , Charles Strother  2 , Guang-Hong Chen  1   2
Affiliations

C-arm cone beam CT perfusion imaging using the SMART-RECON algorithm to improve temporal sampling density and temporal resolution

Yinsheng Li et al. Proc SPIE Int Soc Opt Eng. 2016 Feb-Mar.

Abstract

In this work, a newly developed reconstruction algorithm, Synchronized MultiArtifact Reduction with Tomographic RECONstruction (SMART-RECON), was applied to C-arm cone beam CT perfusion (CBCTP) imaging. This algorithm contains a special rank regularizer, designed to reduce limited-view artifacts associated with super-short scan reconstructions. As a result, high temporal sampling and temporal resolution image reconstructions were achieved using an interventional C-arm x-ray system. The algorithm was evaluated in terms of the fidelity of the dynamic contrast update curves and the accuracy of perfusion parameters through numerical simulation studies. Results shows that, not only were the dynamic curves accurately recovered (relative root mean square error ∈ [3%, 5%] compared with [13%, 22%] for FBP), but also the noise in the final perfusion maps was dramatically reduced. Compared with filtered backprojection, SMART-RECON generated CBCTP maps with much improved capability in differentiating lesions with perfusion deficits from the surrounding healthy brain tissues.

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Figures

Figure 1
Figure 1
Comparison of the arterial input function given by FBP and SMART-RECON with the ground truth.
Figure 2
Figure 2
Comparison of the tissue attenuation curve given by FBP and SMART-RECON with the ground truth.
Figure 3
Figure 3
Comparison of the source images generated by FBP and SMART-RECON.
Figure 4
Figure 4
Comparison of noise standard deviation (STD) of source images generated by FBP and SMART-RECON.
Figure 5
Figure 5
Comparisons of cerebral blood flow (CBF) maps generated by FBP and SMART-RECON with the ground truth.
Figure 6
Figure 6
Comparisons of cerebral blood volume (CBV) maps generated by FBP and SMART-RECON with the ground truth.
Figure 7
Figure 7
Comparisons of mean transit time (MTT) maps generated by FBP and SMART-RECON with the ground truth.
See this image and copyright information in PMC

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