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. 2021 Jul 27:14:3999-4010.
doi: 10.2147/IJGM.S314611. eCollection 2021.

Correlation Analysis of Breast and Thyroid Nodules: A Cross-Sectional Study

Jingtai Chen #  1 , Zhou Xu #  1 , Lingmi Hou  1 , Yunhui Tang  1 , Shuangqiang Qian  1 , Hongyu Pu  1 , Juan Tang  2 , Yanchun Gao  1
Affiliations

Correlation Analysis of Breast and Thyroid Nodules: A Cross-Sectional Study

Jingtai Chen et al. Int J Gen Med. .

Abstract

Objective: Based on physical examination, to explore the relationship between breast mass (BM) and thyroid nodule (TN) prevalence, and to further explore other related factors that affect the occurrence of BM and TN.

Methods: From January 1, 2018, to January 1, 2021, 12,538 female subjects received breast and thyroid ultrasound examinations at the same time in the health examination center of the Affiliated Hospital of North Sichuan Medical College. Univariate analysis and multivariate logistic analysis were used to screen the relevant factors affecting TN and BM, and propensity score matching was used to further verify the results of the relationship between breast and thyroid.

Results: A total of 4975 (39.7%) of the included subjects have BM and a total of 6315 (50.4%) have TN,2557 (20.4%) had both BM and TN. The logistic regression results show that patients with TN are more likely to suffer from BM [OR = 1.185, 95% CI (1.099-1.278), p<0.0001]. In addition, age, free T4, HDL, height, BMI, systolic blood pressure, diastolic blood pressure, and albumin are independent factors affecting the occurrence of BM; patients with BM are more likely to have TN [OR = 1.180, 95% CI (1.094-1.272), p<0.0001], and age, free T3, free T4, AST, ALT, albumin, height, and BMI are independent influencing factors on the occurrence of TN. The result of propensity score matching confirmed the relationship between BM and TN.

Conclusion: There is a bidirectional pathogenic relationship between BM and TN, women with BM are at increased risk of TN, and women with TN are more likely to have BM. Thyroid hormone is not only related to the occurrence of TN but also affects the occurrence of BM.

Keywords: breast; nodule; propensity score analysis; thyroid.

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Conflict of interest statement

The authors declare that they have no conflicts of interest in this work.

References

    1. Wiltshire JJ, Drake TM, Uttley L, Balasubramanian SP. Systematic review of trends in the incidence rates of thyroid cancer. Thyroid. 2016;26(11):1541–1552. doi:10.1089/thy.2016.0100 - DOI - PubMed
    1. Krishnamoorthy Y, Rajaa S, Giriyappa DK, Bharathi A, Velmurugan B, Ganesh K. Worldwide trends in breast cancer incidence from 1993 to 2012: age-period-cohort analysis and joinpoint regression. J Res Med Sci. 2020;25(1):98. doi:10.4103/jrms.JRMS_708_19 - DOI - PMC - PubMed
    1. Pace R, Rahme E, Dasgupta K. Gestational diabetes mellitus and risk of incident primary cancer: a population-based retrospective cohort study. J Diabetes. 2020;12(1):87–90. doi:10.1111/1753-0407.12988 - DOI - PubMed
    1. Kim EY, Chang Y, Lee KH, et al. Serum concentration of thyroid hormones in abnormal and euthyroid ranges and breast cancer risk: a cohort study. Int J Cancer. 2019;145(12):3257–3266. doi:10.1002/ijc.32283 - DOI - PubMed
    1. Lipscombe LL, Fischer HD, Austin PC, et al. The association between diabetes and breast cancer stage at diagnosis: a population-based study. Breast Cancer Res Treat. 2015;150(3):613–620. doi:10.1007/s10549-015-3323-5 - DOI - PubMed