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. 2022 Mar;20(1):172-178.
doi: 10.1111/vco.12759. Epub 2021 Aug 10.

A retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy

Penelope Banchi  1 , Emanuela Maria Morello  1 , Alessia Bertero  2 , Alessandro Ricci  1 , Ada Rota  1
Affiliations
Free article

A retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy

Penelope Banchi et al. Vet Comp Oncol. 2022 Mar.
Free article

Abstract

The aim of the present study was to retrospectively assess whether spaying at the same time of mastectomy increased disease-free survival (DFS) in bitches with mammary tumours and to investigate the utility of clinical data when designing a surgical plan that includes gonadectomy. Characteristics of 225 bitches carrying 489 tumours were retrieved. Of the116 bitches that underwent surgery, 52 bitches underwent mastectomy and ovariectomy, 46 bitches underwent mastectomy alone, whereas 18 bitches were already spayed. Analysis by Kaplan-Meier and in-between groups comparisons using Student's T, Chi-square, and one-way ANOVA tests were performed. DFS was longer for bitches that underwent ovariectomy and mastectomy compared to those that were left intact (p = .00064) or were already spayed (p = .0098). Spaying status affected tumour size (spayed: 2.75 cm ± 2.72; intact: 1.76 cm ± 2.04; p = .039), but not malignancy (p > .05). Differences in age were detected between animals with benign and malignant tumours (years: 9.1 ± 2.8 and 10 ± 2.3; p = .004), with multiple and single tumours (years: 10.18 ± 2.6 and 9.3 ± 2.8; p = .007), and between purebred and mixed breed bitches (years: 10.46 ±1.78 and 9.27 ±2.68; p = .005). Malignant tumours were larger than benign ones (2.17 cm±2.31 and 1.34 cm ±1.82; p = .005) and size increased according to the degree of malignancy. DFS was shorter for animals presenting tumours >2 cm in size (p < .006) and with tumours in the first pair of thoracic mammary glands (p = .00009). Gonadectomy should be suggested to owners of intact bitches carrying mammary tumours and age, size of the tumour, and location should be carefully considered when performing surgery.

Keywords: dog; gonadectomy; mammary tumour; mastectomy; ovariectomy.

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References

REFERENCES

    1. Sleeckx N, de Rooster H, Veldhuis Kroeze E, Van Ginneken C, Van Brantegem L. Canine mammary tumours, an overview. Reprod Domest Anim. 2011;46:1112-1131.
    1. MacEwen EG, Patnaik AK, Harvey HJ, Panko WB. Estrogen receptors in canine mammary tumors. Cancer Res. 1982;42(6):2255-2259.
    1. Rutteman GR, Misdorp W, Blankenstein MA, van den Brom WE. Oestrogen (ER) and progestin receptors (PR) in mammary tissue of the female dog: different receptor profile in non-malignant and malignant states. Br J Cancer. 1988;58(5):594-599.
    1. Mainenti M, Rasotto R, Carnier P, Zappulli V. Oestrogen and progesterone receptor expression in subtypes of canine mammary tumours in intact and ovariectomised dogs. Vet J. 2014;202(1):62-68.
    1. Queiroga FL, Pérez-Alenza MD, Silvan G, Peña L, Lopes C, Illera JC. Role of steroid hormones and prolactin in canine mammary cancer. J Steroid Biochem Mol Biol. 2005;94(1-3):181-187.