Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Aug 6;129(4):471-473.
doi: 10.1161/CIRCRESAHA.121.319722. Epub 2021 Aug 5.

ADAMTS7 Knockdown in Context: Emerging Therapeutic Targets in Atherothrombosis

Matthew J Feinstein  1   2 , Edward B Thorp  3   2   4
Affiliations
Editorial

ADAMTS7 Knockdown in Context: Emerging Therapeutic Targets in Atherothrombosis

Matthew J Feinstein et al. Circ Res. .
No abstract available

Keywords: Editorials; apolipoproteins; atherosclerosis; cardiovascular diseases; humans; mutation.

PubMed Disclaimer

Figures

Figure.
Figure.. Novel and emerging genetic and molecular targets in atherothrombosis.
Several potential therapeutic targets related to atherosclerosis and thrombosis have emerged in recent years, including both lipid-focused and less lipid-focused targets. These include genetic and molecular targets and correspond to known key mediators of athero-thrombosis. Selected emerging targets are depicted in the figure. ADAMTS7 indicates the gene ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7; ANGPTL4, the gene for angiopoietin like 4; ApoB, apolipoprotein B; ASGR1, the gene for asialogycoprotein receptor 1; CCR5, the gene for C-C chemokine receptor 5; CD47, for cluster of differentiation 47; IL-1B, interleukin 1-beta; IL-6, interleukin-6; LDL, low density lipoprotein; Mcp1, the gene for monocyte chemoattractant protein 1; MIA3, the gene for melanoma inhibitory protein 3; PCSK9, the gene for proprotein convertase subtilisin/kexin type 9; TMAO, trimethylamine N-oxide; TREM-1, triggering receptor expressed on myeloid cells 1; vLDL, very low density lipoprotein; VSMC, vascular smooth muscle cell.
See this image and copyright information in PMC

Comment on

  • Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.
    Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini A, Lai D, Zhu QM, Xing Y, Kaushik VK, Kathiresan S, Ellinor PT. Mizoguchi T, et al. Circ Res. 2021 Aug 6;129(4):458-470. doi: 10.1161/CIRCRESAHA.121.319163. Epub 2021 Jun 28. Circ Res. 2021. PMID: 34176299 Free PMC article.

References

    1. Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003;34:154–6. - PubMed
    1. Cohen JC, Boerwinkle E, Mosley TH Jr. and Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. The New England journal of medicine. 2006;354:1264–72. - PubMed
    1. Ray KK, Wright RS, Kallend D, et al. Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol. N Engl J Med. 2020;382:1507–1519. - PubMed
    1. Musunuru K, Chadwick AC, Mizoguchi T, et al. In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates. Nature. 2021;593:429–434. - PubMed
    1. Kimura T, Kobiyama K, Winkels H, et al. Regulatory CD4(+) T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B. Circulation. 2018;138:1130–1143. - PMC - PubMed