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. 2023 Jan;37(2):240-247.
doi: 10.1080/14786419.2021.1961253. Epub 2021 Aug 5.

Triterpenoids from the bark of Entandrophragma angolense

Binh T D Trinh  1   2   3 , Dzung N Bui  1   3 , Ly T T Nguyen  1   3 , Hieu T Nguyen  3   4 , Chi N Nguyen  1   3 , Lien-Hoa D Nguyen  1   3   4 , Tuyen N M Huynh  1   3 , Tien T C Cao  1   3 , Le-Thu T Nguyen  1   3
Affiliations

Triterpenoids from the bark of Entandrophragma angolense

Binh T D Trinh et al. Nat Prod Res. 2023 Jan.

Abstract

Two new triterpenoids, entanolide (1) and methyl 3,4-secotirucalla-23-oxo-4(28),7,24-trien-21-al-3-oate (2), together with nine known compounds (3-11), were isolated from the bark of Entandrophragma angolense. Their structures were elucidated based on spectroscopic analyses, mainly 1 D and 2 D NMR spectral data. Compounds 1-6 and 8 were evaluated for their cytotoxicity against HepG2 cells, and compounds 2-5 exhibited weak activities.

Keywords: Entandrophragma angolense; Meliaceae; cytotoxicity; triterpenoids.

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