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. 1987 Sep;289(1):11-7.

Liver microsomal benznidazole and nifurtimox nitroreductase activity in male rats of different age

E Aguilar  1 , C K de Arranz, E G de Toranzo, J A Castro
Affiliations
  • PMID: 3435199

Liver microsomal benznidazole and nifurtimox nitroreductase activity in male rats of different age

E Aguilar et al. Arch Int Pharmacodyn Ther. 1987 Sep.

Abstract

Nifurtimox (Nfx) and Benznidazole (Bz) are 2 drugs used in the chemotherapy of Chagas' disease, a sickness afflicting millions of Latin Americans. Their toxicity is related to nitroreductive activation. Nfx and Bz nitroreductase activity in liver microsomes from male rats is already present at low levels in the newborn and reaches full adult activity in 28 days. This suggests a better therapeutic approach by starting the treatment of transplacentally acquired Chagas' disease immediately after birth.

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