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Comment
. 2021 Aug 4;109(15):2363-2365.
doi: 10.1016/j.neuron.2021.07.013.

ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue

Andrew S Mendiola  1 , Reshmi Tognatta  1 , Zhaoqi Yan  1 , Katerina Akassoglou  2
Affiliations
Comment

ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue

Andrew S Mendiola et al. Neuron. .

Abstract

In this issue of Neuron, Shi et al. (2021) show a protective role for the low-density lipoprotein receptor (LDLR) in tau pathology. Brain overexpression of LDLR lowers apolipoprotein E (apoE), suppresses microglial activation, preserves myelin, and ameliorates neurodegeneration, pointing the way toward potential new therapies.

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Conflict of interest statement

Declaration of Interests K.A. is the scientific founder, advisor, and a board director of Therini Bio, Inc. Her interests are managed by the Gladstone Institutes according to its conflict of interest policy.

Figures

Figure 1:
Figure 1:
Protective effects of LDLR overexpression in tauopathy.
See this image and copyright information in PMC

Comment on

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