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. 2021 Aug 4;109(15):2365-2367.
doi: 10.1016/j.neuron.2021.07.010.

HepaCAM shapes astrocyte territories, stabilizes gap-junction coupling, and influences neuronal excitability

Michael V Sofroniew  1
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HepaCAM shapes astrocyte territories, stabilizes gap-junction coupling, and influences neuronal excitability

Michael V Sofroniew. Neuron. .
Free article

Abstract

How astrocytes form non-overlapping territories within synaptic neuropil is not understood. In this issue of Neuron, Baldwin et al. (2021) report that the cell adhesion molecule hepaCAM shapes murine astrocyte territories and that hepaCAM loss impairs gap-junction cell coupling and the balance between synaptic excitation and inhibition.

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  • HepaCAM controls astrocyte self-organization and coupling.
    Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras X, Rülicke T, Hippenmeyer S, Estévez R, Ji RR, Eroglu C. Baldwin KT, et al. Neuron. 2021 Aug 4;109(15):2427-2442.e10. doi: 10.1016/j.neuron.2021.05.025. Epub 2021 Jun 24. Neuron. 2021. PMID: 34171291 Free PMC article.

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