ASTE1 cutting to block DNA end resection

Yizhou Joseph He¹, Dipanjan Chowdhury^{2

3

4}

Affiliations

¹ Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
² Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. dipanjan_chowdhury@dfci.harvard.edu.
³ Broad Institute of Harvard and MIT, Cambridge, MA, USA. dipanjan_chowdhury@dfci.harvard.edu.
⁴ Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. dipanjan_chowdhury@dfci.harvard.edu.

Comment

Yizhou Joseph He et al. Nat Cell Biol. 2021 Aug.

. 2021 Aug;23(8):818-819.

doi: 10.1038/s41556-021-00731-9.

Yizhou Joseph He¹, Dipanjan Chowdhury^{2

3

4}

¹ Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
² Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. dipanjan_chowdhury@dfci.harvard.edu.
³ Broad Institute of Harvard and MIT, Cambridge, MA, USA. dipanjan_chowdhury@dfci.harvard.edu.
⁴ Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. dipanjan_chowdhury@dfci.harvard.edu.

No abstract available

Comment on

ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection.
Zhao F, Kim W, Gao H, Liu C, Zhang Y, Chen Y, Deng M, Zhou Q, Huang J, Hu Q, Chen SH, Nowsheen S, Kloeber JA, Qin B, Yin P, Tu X, Guo G, Qin S, Zhang C, Gao M, Luo K, Liu Y, Lou Z, Yuan J. Zhao F, et al. Nat Cell Biol. 2021 Aug;23(8):894-904. doi: 10.1038/s41556-021-00723-9. Epub 2021 Aug 5. Nat Cell Biol. 2021. PMID: 34354233

1. Ceccaldi, R., Rondinelli, B. & D’Andrea, A. D. Trends Cell Biol. 26, 52–64 (2016). - DOI - PubMed
1. Tarsounas, M. & Sung, P. Nat. Rev. Mol. Cell Biol. 21, 284–299 (2020). - PubMed - PMC
1. Cao, L. et al. Mol. Cell 35, 534–541 (2009). - DOI - PubMed - PMC
1. Noordermeer, S. M. et al. Nature 560, 117–121 (2018). - DOI - PubMed - PMC
1. Mirman, Z. et al. Nature 560, 112–116 (2018). - DOI - PubMed - PMC