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Comment
. 2021 Sep;22(9):1078-1079.
doi: 10.1038/s41590-021-01002-3.

Targeting resident macrophages in cancer

Xin Li  1 , Kavita Rawat  1 , Claudia V Jakubzick  2
Affiliations
Comment

Targeting resident macrophages in cancer

Xin Li et al. Nat Immunol. 2021 Sep.
No abstract available

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Figures

Fig. 1 ∣
Fig. 1 ∣. TAM diversity and AM function in lung tumors in human and mouse.
a, Single-cell RNA sequencing identified four distinct macrophage and monocyte clusters in non-involved (naive) and tumor-bearing lungs in humans with NSCLC and in an orthotopic mouse model of NSCLC (KrasG12D and p53-deficient (KP) lung epithelial cells). TRM-AMs, group I; MDMs, group II; CD14+ monocytes, group III; and CD16+ monocytes, group IV. rec-MDM, recruited MDM. b, Selective depletion of CD169+ AMs in the early stages of tumor progression (day 0–3) induces changes in the ratio of CD8+ T cells to Treg cells in the tumor environment. EMT, epithelial–mesenchymal transition.
See this image and copyright information in PMC

Comment on

  • Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.
    Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Casanova-Acebes M, et al. Nature. 2021 Jul;595(7868):578-584. doi: 10.1038/s41586-021-03651-8. Epub 2021 Jun 16. Nature. 2021. PMID: 34135508 Free PMC article.

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