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. 2021 Aug;26(31):2100640.
doi: 10.2807/1560-7917.ES.2021.26.31.2100640.

Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021

Brechje de Gier  1 , Stijn Andeweg  1 , Rosa Joosten  1 , Ronald Ter Schegget  2 , Naomi Smorenburg  1 , Jan van de Kassteele  1 ; RIVM COVID-19 surveillance and epidemiology team 1,  3 ; Susan Jm Hahné  1 , Susan van den Hof  1 , Hester E de Melker  1 , Mirjam J Knol  1 ; Members of the RIVM COVID-19 surveillance and epidemiology team
Collaborators, Affiliations

Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021

Brechje de Gier et al. Euro Surveill. 2021 Aug.

Abstract

Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63-77).

Keywords: COVID-19; SARS-CoV-2; household study; transmission; vaccine effectiveness.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Crude attack rate of SARS-CoV-2 among contacts, by vaccination status of the index (left to right) and vaccination status of the contact (top to bottom), the Netherlands, 1 February−27 May 2021 (n = 113,582 index cases, n = 253,168 contacts)
See this image and copyright information in PMC

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