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Observational Study
. 2022 Sep;47(9):3338-3344.
doi: 10.1007/s00261-021-03207-4. Epub 2021 Aug 6.

Complications of percutaneous transhepatic cholangiography and biliary drainage, a multicenter observational study

Ayla S Turan  1 , Sjoerd Jenniskens  2 , Jasper M Martens  3 , Matthieu J C M Rutten  2   4 , Lonneke S F Yo  5 , Marco J L van Strijen  6 , Joost P H Drenth  7 , Peter D Siersema  7 , Erwin J M van Geenen  7
Affiliations
Observational Study

Complications of percutaneous transhepatic cholangiography and biliary drainage, a multicenter observational study

Ayla S Turan et al. Abdom Radiol (NY). 2022 Sep.

Abstract

Objectives: Over 2500 percutaneous transhepatic cholangiography and biliary drainage (PTCD) procedures are yearly performed in the Netherlands. Most interventions are performed for treatment of biliary obstruction following unsuccessful endoscopic biliary cannulation. Our aim was to evaluate complication rates and risk factors for complications in PTCD patients after failed ERCP.

Methods: We performed an observational study collecting data from a cohort that was subjected to PTCD during a 5-year period in one academic and four teaching hospitals. Primary objective was the development of infectious (sepsis, cholangitis, abscess, or cholecystitis) and non-infectious complications (bile leakage, severe hemorrhage, etc.) and mortality within 30 days of the procedure. Subsequently, risk factors for complications and mortality were analyzed with a multilevel logistic regression analysis.

Results: A total of 331 patients underwent PTCD of whom 205 (61.9%) developed PTCD-related complications. Of the 224 patients without a pre-existent infection, 91 (40.6%) developed infectious complications, i.e., cholangitis in 26.3%, sepsis in 24.6%, abscess formation in 2.7%, and cholecystitis in 1.3%. Non-infectious complications developed in 114 of 331 patients (34.4%). 30-day mortality was 17.2% (N = 57). Risk factors for infectious complications included internal drainage and drain obstruction, while multiple re-interventions were a risk factor for non-infectious complications.

Conclusion: Both infectious and non-infectious complications are frequent after PTCD, most often due to biliary drain obstruction.

Keywords: Antibiotics; Complications; Infection; PTC (D); Prophylaxis.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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