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. 2021 Aug;189(3):e141.
doi: 10.1002/vetr.141. Epub 2021 Feb 10.

Calcium oxalate urolithiasis in juvenile dogs

Alexander Saver  1 , Jody P Lulich  2 , Samantha Van Buren  2 , Eva Furrow  2
Affiliations

Calcium oxalate urolithiasis in juvenile dogs

Alexander Saver et al. Vet Rec. 2021 Aug.

Abstract

Background: The features of juvenile-onset calcium oxalate urolithiasis in dogs have not been previously reported.

Methods: Calcium oxalate urolith submissions to the Minnesota Urolith Center between 2012 and 2016 were analyzed to identify those originating from juvenile (≤2 years, n = 510) or mature (7-9 years, n = 39,093) dogs. Breed, sex, urolith salt type and urolith location were compared between groups. Breeds represented in both groups were also compared with respect to sex, urolith salt type and urolith location.

Results: French (odds ratios [OR] = 14.7, p < 0.001) and English (OR = 14.3, p < 0.001) Bulldogs were overrepresented in juvenile submissions. All juvenile French and English Bulldogs were male. Across all breeds, juvenile dogs were more likely to be male (89%, p < 0.001) than mature dogs (79%). Juvenile dogs were also more likely to form dihydrate stones compared to mature dogs (33% versus 14%, respectively; p < 0.001). Breed differences were discovered in sex, urolith salt type and stone location.

Conclusions: French and English Bulldogs comprise a greater proportion of juvenile calcium oxalate urolith submissions than expected based on their rarity in mature submissions. Inherited risk factors, particularly X chromosome variants, should be investigated due to the strong breed and sex predispositions identified.

Keywords: bulldog; hyperuricosuria; paediatric; predispositions; urinary stones.

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Conflict of interest statement

COMPETING INTERESTS

The authors declare no conflict of interest.

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