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. 2021 Nov;46(6):1331-1338.
doi: 10.1111/coa.13844. Epub 2021 Aug 16.

Virus load and incidence of olfactory, gustatory, respiratory, gastrointestinal disorders in COVID-19 patients: A retrospective cohort study

Mohammad Hosein Taziki Balajelini  1 , Abdolhalim Rajabi  2 , Masoud Mohammadi  3 , Hadi Razavi Nikoo  4 , Alijan Tabarraei  4 , Mohsen Mansouri  5 , Seyed Mehran Hosseini  6
Affiliations

Virus load and incidence of olfactory, gustatory, respiratory, gastrointestinal disorders in COVID-19 patients: A retrospective cohort study

Mohammad Hosein Taziki Balajelini et al. Clin Otolaryngol. 2021 Nov.

Abstract

Objectives: This study investigated the relationship between viral load and the incidence of olfactory and gustatory dysfunction (OD and GD), the incidence of respiratory and gastrointestinal symptoms and the recovery of OD and GD in COVID-19 patients.

Design: A retrospective cohort study.

Setting and participants: This study was conducted on 599 outpatients' cases in Golestan province between February and June 2020.

Main outcome measures: The incidence, severity (complete or partial) and recovery time of OD and GD and their associations with cycle threshold (CT) values of SARS-CoV-2 polymerase chain reaction were assessed.

Results: The mean age of patients was 38.27 ± 13.62 years. The incidence of general symptoms included myalgia 70.1%, headache 51.8%, fever 47.7% and dyspnoea 21.4%. 41.9% of patients had gastrointestinal symptoms, including abdominal pain 26.5%, diarrhoea 25.2%, nausea 20.5% and vomiting 12.9%. 12.2% of patients had comorbidity. The trimester recovery rates of OD and GD were 93.94% and 94.74% respectively. The mean recovery time of OD and GD was 14.56 ± 13.37 and 13.8 ± 3.77 days respectively. The mean CT value in all patients was 27.45 ± 4.55. There were significant associations between the mean of CT value with headache (p = 0.04), GD (p = 0.002) and OD (p = 0.001).

Conclusions: The finding of this study indicates a possible association between viral load with incidence of OD and GD in COVID-19 patient's cases and assures the recovery of OD/GD in these patients.

Keywords: COVID-19; gustatory disorders; olfaction disorders; taste disorders; viral load.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
Matrix correlation between the recovery time of OD, GD and CT
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