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Comment
. 2021 Aug 5;28(8):1335-1336.
doi: 10.1016/j.stem.2021.07.006.

Infection makes micro-CHIPs into macro-CHIPs

Jayakrishnan Gopakumar  1 , Siddhartha Jaiswal  2
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Infection makes micro-CHIPs into macro-CHIPs

Jayakrishnan Gopakumar et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Hormaechea-Agulla et al. (2021) demonstrate that IFNγ signaling following an infection in mice provides a selective pressure that drives growth of Dnmt3a-/- hematopoietic stem cells. This clonal expansion is mediated by global methylation changes that lead to an increased self-renewing capacity.

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