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Review
. 2021 Jul 19;10(7):1660.
doi: 10.3390/foods10071660.

Hizikia fusiformis: Pharmacological and Nutritional Properties

Maria Dyah Nur Meinita  1   2   3 , Dicky Harwanto  1   4 , Jae-Hak Sohn  1   5 , Jin-Soo Kim  6 , Jae-Suk Choi  1   5
Affiliations
Review

Hizikia fusiformis: Pharmacological and Nutritional Properties

Maria Dyah Nur Meinita et al. Foods. .

Abstract

The brown seaweed Hizikia fusiformis (syn. Sargassum fusiforme), commonly known as "Hijiki", has been utilized in traditional cuisine and medicine in East Asian countries for several centuries. H. fusiformis has attracted much attention owing to its rich nutritional and pharmacological properties. However, there has been no comprehensive review of the nutritional and pharmacological properties of H. fusiformis. The aim of this systematic review was to provide detailed information from the published literature on the nutritional and pharmacological properties of H. fusiformis. A comprehensive online search of the literature was conducted by accessing databases, such as PubMed, SpringerLink, ScienceDirect, and Google Scholar, for published studies on the nutritional and pharmacological properties of H. fusiformis between 2010 and 2021. A total of 916 articles were screened from all the databases using the preferred reporting items for systematic reviews and meta-analyses method. Screening based on the setdown criteria resulted in 59 articles, which were used for this review. In this review, we found that there has been an increase in the number of publications on the pharmacological and nutritional properties of H. fusiformis over the last 10 years. In the last 10 years, studies have focused on the proximate, mineral, polysaccharide, and bioactive compound composition, and pharmacological properties, such as antioxidant, anticancer, antitumor, anti-inflammatory, photoprotective, neuroprotective, antidiabetic, immunomodulatory, osteoprotective, and gastroprotective properties of H. fusiformis extracts. Overall, further studies and strategies are required to develop H. fusiformis as a promising resource for the nutrition and pharmacological industries.

Keywords: Hizikia fusiformis; Sargassum fusiforme; hijiki; nutritional properties; pharmacological properties.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Summarized search method based on the PRISMA method.
Figure 2
Figure 2
The number of publications related to the nutritional and pharmacological properties of H. fusiformis.
Figure 3
Figure 3
Current research trends of the pharmacological properties of H. fusiformis.
Figure 4
Figure 4
Basic chemical structure of fucoidan.
Figure 5
Figure 5
Chemical structures of arsenic compounds found in H. fusiformis. (1) Arsenite (As(III)); (2) arsenate (As(V)); (3) monomethylarsonic acid (MMA(V)); (4) dimethylarsinic acid (DMA(V)); (5) arsenobetaine (AsB); (6) arsenocholine (AsC).
Figure 6
Figure 6
The chemical structures of bioactive compounds in H. fusiformis. (1) phlorotannins; (2) glycyrrhizin; (3) tetradecanoic acid; (4) palmitic acid; (5) 9-hexadecenoic acid; (6) phytol; (7) arachidonic acid; (8) fucoxanthin; (9) saringosterol; (10) fucosterol; (11) alginate; (12) lectin.
See this image and copyright information in PMC

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