Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug 1;13(15):3882.
doi: 10.3390/cancers13153882.

Interactions Networks for Primary Heart Sarcomas

Styliani A Geronikolou  1   2   3 , Athanasia Pavlopoulou  4   5 , George P Chrousos  1   2   3 , Dennis V Cokkinos  1
Affiliations

Interactions Networks for Primary Heart Sarcomas

Styliani A Geronikolou et al. Cancers (Basel). .

Abstract

Personalized medicine incorporates genetic information into medical practice so as to optimize the management of chronic diseases. In rare diseases, such as heart cancer (incidence 0.0017-0.33%), this may be elusive. Ninety-five percent of the cases are due to secondary involvementwith the neoplasm originating in the lungs, breasts, kidney, blood, or skin. The clinical manifestations of heart tumors (benign or malignant) include heart failure, hypertension, and cardiac arrhythmias of varying severity, frequently resulting in blood vessel emboli, including strokes. This study aims to explain the pathophysiology and contribute to a P4 medicine model for use by cardiologists, pathologists, and oncologists. We created six gene/protein heart-related and tumor-related targets high-confidence interactomes, which unfold the main pathways that may lead to cardiac diseases (heart failure, hypertension, coronary artery disease, arrhythmias), i.e., the sympathetic nervous system, the renin-angiotensin-aldosterone axis and the endothelin pathway, and excludes others, such as the K oxidase or cytochrome P450 pathways. We concluded that heart cancer patients could be affected by beta-adrenergic blockers, ACE inhibitors, QT-prolonging antiarrhythmic drugs, antibiotics, and antipsychotics. Interactomes may elucidate unknown pathways, adding to patient/survivor wellness during/after chemo- and/or radio-therapy.

Keywords: case report; heart failure treatment; heart sarcoma; interactome; personalized medicine; primary heart cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The heart angiosarcoma interactome.
Figure 2
Figure 2
The heart undifferentiated sarcoma interactome.
Figure 3
Figure 3
The heart rhabdomyosarcoma interactome.
Figure 4
Figure 4
The heart leiomyosarcoma interactome.
Figure 5
Figure 5
The heart myxofibrosarcoma interactome.
Figure 6
Figure 6
The heart synovial sarcoma interactome.
Figure 7
Figure 7
ED3: a representative case of angiosarcoma of the right atrium in a 40-year-old woman: blood vessels are covered by atypical endothelial cells and surrounded by spindle cells.
Figure 8
Figure 8
Workflow chart representing the algorithm followed in this work.
See this image and copyright information in PMC

References

    1. Wulff H.R. The concept of disease: From Newton back to Aristotle. Lancet. 1999;54:354. doi: 10.1016/S0140-6736(99)90393-8. - DOI - PubMed
    1. Leopold J.A., Loscalzo J. Emerging Role of Precision Medicine in Cardiovascular Disease. Circ. Res. 2018;122:1302–1315. doi: 10.1161/CIRCRESAHA.117.310782. - DOI - PMC - PubMed
    1. Krzyszczyk P., Acevedo A., Davidoff E.J., Timmins L.M., Marrero-Berrios I., Patel M., White C., Lowe C., Sherba J.J., Hartmanshenn C., et al. The growing role of precision and personalized medicine for cancer treatment. Technology. 2018;6:79–100. doi: 10.1142/S2339547818300020. - DOI - PMC - PubMed
    1. Adams K.F. Systems biology and heart failure: Concepts, methods, and potential research applications. Heart Fail. Rev. 2010;15:371–398. doi: 10.1007/s10741-009-9138-x. - DOI - PubMed
    1. Ren D.Y., Fuller N.D., Gilbert S.A.B., Zhang Y. Cardiac Tumors: Clinical Perspective and Therapeutic Considerations. Curr. Drug Targets. 2017;18:1805–1809. doi: 10.2174/1389450117666160703162111. - DOI - PubMed

LinkOut - more resources