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Review
. 2021 Jul 28;26(15):4564.
doi: 10.3390/molecules26154564.

A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

José M Cela-López  1 , Claudio J Camacho Roldán  1 , Gorka Gómez-Lizarraga  1 , Vicente Martínez  1
Affiliations
Review

A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

José M Cela-López et al. Molecules. .

Abstract

Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and lead to the creation of resistance and are associated with increased morbidity and mortality. For this reason, it is necessary to develop new compounds for their treatment. In this work, our objective is to review the characteristics of the compounds of a new formulation called Itxasol© that is prescribed as an adjuvant for the treatment of UTIs and composed of β-arbutin, umbelliferon and n-acetyl cysteine. This formulation, based on biomimetic principles, makes Itxasol© a broad-spectrum antibiotic with bactericidal, bacteriostatic and antifungal properties that is capable of destroying the biofilm and stopping its formation. It also acts as an anti-inflammatory agent, without the adverse effects associated with the recurrent use of antibiotics that leads to renal nephrotoxicity and other side effects. All these characteristics make Itxasol© an ideal candidate for the treatment of UTIs since it behaves like an antibiotic and with better characteristics than other adjuvants, such as D-mannose and cranberry extracts.

Keywords: N-acetyl l-cysteine; arbutin; umbelliferon; urinary tract infections.

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Conflict of interest statement

José M. Cela-López, Claudio J Camacho Roldán, Gorka Gómez Lizarraga and Vicente Martínez belong to Naturmimetix, the company that developed Itxasol©.

Figures

Figure 1
Figure 1
Chemical structure of arbutin, hydoquinone and D-Glucose.
Figure 2
Figure 2
Chemical structure of UMB.
Figure 3
Figure 3
Chemical structure of NAC.
Figure 4
Figure 4
Combined mechanism of action of the three components of Itxasol©: β-arbutin, UMB and NAC.
See this image and copyright information in PMC

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