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. 2021 Jul 22;10(15):3233.
doi: 10.3390/jcm10153233.

Retinal OCT Findings in Patients after COVID Infection

Dominika Szkodny  1   2 , Edward Wylęgała  1   2 , Paulina Sujka-Franczak  2 , Edyta Chlasta-Twardzik  1   2 , Rafał Fiolka  1   2 , Tomasz Tomczyk  3 , Adam Wylęgała  1   2
Affiliations

Retinal OCT Findings in Patients after COVID Infection

Dominika Szkodny et al. J Clin Med. .

Abstract

Purpose: The aim of this study was to assess and compare the optic nerve, retina, and retinal vessel parameters in recovered COVID-19 patients and healthy patients by using optical coherence tomography angiography (OCT-a).

Methods: In all, 156 eyes of post-COVID-19 patients and 98 eyes of subjects from a control group were enrolled in our study. BCVA, intra ocular pressure (IOP) measurement, fundus examination, and OCT images, including macular cube, OCT-RNFL, and angio-OCT 6 × 6 mm examinations, were performed for both groups. The measurements were acquired using Swept Source OCT DRI OCT Triton. In the post-COVID-19 group, 762 OCT protocols were obtained. For statistical analysis, parameters from only one eye from each subject were taken.

Results: In the measured parameters, no significant differences were observed, i.e., central macular thickness (p = 0.249); RNFL (p = 0.104); FAZ (p = 0.63); and vessel density of superficial retinal vascular plexus in central (p = 0.799), superior (p = 0.767), inferior (p = 0.526), nasal (p = 0.402), and temporal (p = 0.582) quadrants. Furthermore, a slit-lamp examination did not reveal any COVID-19-related abnormalities.

Conclusion: OCT examination did not detect any significant changes in morphology or morphometry of the optic nerve, retina, or the retina vessels due to COVID-19.

Keywords: COVID-19; angiography; choroid; optical coherence tomography; retina; vascular complications.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Optical coherence tomography angiograms of a patient, one month from COVID-19 onset. There are no remarkable abnormalities present.
See this image and copyright information in PMC

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References

    1. Zheng Y.-Y., Ma Y.-T., Zhang J.-Y., Xie X. COVID-19 and the cardiovascular system. Nat. Rev. Cardiol. 2020;17:259–260. doi: 10.1038/s41569-020-0360-5. - DOI - PMC - PubMed
    1. Soiza R.L., Donaldson A.I.C., Myint P.K. Vaccine against arteriosclerosis: An update. Ther. Adv. Vaccines. 2018;9:259–261.
    1. Gupta A., Madhavan M.V., Sehgal K., Nair N., Mahajan S., Sehrawat T.S., Bikdeli B., Ahluwalia N., Ausiello J.C., Wan E.Y., et al. Extrapulmonary manifestations of COVID-19. Nat. Med. 2020;26:1017–1032. doi: 10.1038/s41591-020-0968-3. - DOI - PMC - PubMed
    1. Abrishami M., Emamverdian Z., Shoeibi N., Omidtabrizi A., Daneshvar R., Rezvani T.S., Saeedian N., Eslami S., Mazloumi M., Sadda S., et al. Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: A case-control study. Can. J. Ophthalmol. 2021;56:24–30. doi: 10.1016/j.jcjo.2020.11.006. - DOI - PMC - PubMed
    1. Douglas K.A.A., Douglas V.P., Moschos M.M. Ocular manifestations of COVID-19 (SARS-CoV-2): A critical review of current literature. In Vivo. 2020;34:1619–1628. doi: 10.21873/invivo.11952. - DOI - PMC - PubMed

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