Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 27;10(15):3312.
doi: 10.3390/jcm10153312.

Liposomal Inhalation after Tracheostomy-A Randomized Controlled Trial

Benedikt Hofauer  1 , Ulrich Straßen  1 , Adam Chaker  1 , Beate Schossow  2 , Magdalena Wirth  1 , Markus Wirth  1 , Murat Bas  1 , Andreas Knopf  3
Affiliations

Liposomal Inhalation after Tracheostomy-A Randomized Controlled Trial

Benedikt Hofauer et al. J Clin Med. .

Abstract

Background: Tracheostomy is a common procedure in critical care. The aim of this study was to evaluate the application of a liposomal inhalation compared to standard physiologic saline (SPS) inhalation on basis of objective and subjective parameters of airway inflammation.

Methods: We evaluated in this two-armed, double-blinded and randomized control group study the effect of liposomal compared with SPS inhalation in newly tracheotomized patients. The primary endpoint was defined as trend of tracheobronchial IL-6 secretion at day 1 compared to day 10. Further objective and subjective parameter were evaluated.

Results: Fifty patients were randomized in each arm. Tracheal IL-6 levels decreased significantly only after liposomal inhalation. Both inhalative agents seem to have an effect on the respiratory impairment after tracheostomy. Subjective patient impairment was reduced significantly from day 1 to day 10 after tracheostomy with liposomal inhalation.

Conclusions: Liposomal inhalation demonstrated an advantage over SPS inhalation in newly tracheotomized patients.

Keywords: inhalation; interleukin; liposomes; physiological saline solution; tracheostomy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Illustration of the study flow.
Figure 2
Figure 2
CONSORT flow chart.
Figure 3
Figure 3
Effect of liposomal and physiologic saline solution inhalation on tracheal IL-6 level at day 1, day 3 and day 10 after tracheostomy.
See this image and copyright information in PMC

References

    1. Pignatti P., Balestrino A., Herr C., Bals R., Moretto D., Corradi M., Alinovi R., Delmastro M., Vogelmeier C., Nava S., et al. Tracheostomy and related host-pathogen interaction are associated with airway inflammation as characterized by tracheal aspirate analysis. Respir. Med. 2009;103:201–208. doi: 10.1016/j.rmed.2008.09.008. - DOI - PubMed
    1. Klemm E., Nowak A.K. Tracheotomy-Related Deaths. Dtsch. Arztebl. Int. 2017;114:273–279. - PMC - PubMed
    1. Hill N.S. Neuromuscular disease in respiratory and critical care medicine. Respir. Care. 2006;51:1065–1071. - PubMed
    1. Kanna B., Ayman H.A., Soni A. Early tracheostomy in intensive care trauma patient improves resource utilization: A cohort study and literature review. Lett. Crit. Care. 2005;9:414–416. doi: 10.1186/cc3043. - DOI - PMC - PubMed
    1. Cox C.E., Carson S.S., Holmes G.M., Howard A., Carey T.S. Increase in tracheostomy for prolonged mechanical ventilation in North Carolina, 1993–2002. Crit. Care Med. 2004;32:2219–2226. doi: 10.1097/01.CCM.0000145232.46143.40. - DOI - PubMed

LinkOut - more resources