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. 2021 Nov;101(3):115507.
doi: 10.1016/j.diagmicrobio.2021.115507. Epub 2021 Jul 23.

Algorithm for rational use of Film Array Pneumonia Panel in bacterial coinfections of critically ill ventilated COVID-19 patients

Emmanuel Novy  1 , Antoine Goury  2 , Carine Thivilier  3 , Thomas Guillard  4 , Corentine Alauzet  5
Affiliations

Algorithm for rational use of Film Array Pneumonia Panel in bacterial coinfections of critically ill ventilated COVID-19 patients

Emmanuel Novy et al. Diagn Microbiol Infect Dis. 2021 Nov.

Abstract

The FilmArray Pneumonia Panel has proven to be an effective tool for rapid detection of main respiratory pathogens. However, its rational use needs appropriate knowledge and formation regarding its indication and interpretation. Herein, we provide some advices to help with success of its daily routine use, particularly in critically ill ventilated COVID-19 patients. Clinical Trial registration number: NCT04453540.

Keywords: Antimicrobial stewardship; Bacterial coinfection; Covid-19; Critically ill; Molecular diagnosis; Pneumonia.

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Figures

Fig 1
Fig. 1
Clinical algorithm for initiating antibiotics using FAPP in bacterial coinfection of critically ill COVID-19 patients. IMV, invasive mechanical ventilation; BAL, bronchoalveolar lavage; FAPP, FilmArray® Pneumonia Panel; ATB, antibiotics; GNB, Gram-negative bacilli. a Endotracheal aspirate samples could be used but need cautious interpretation regarding the risk of over-diagnosis due to tracheobronchial colonization; b Septic shock (according to SEPSIS-3) or severe ARDS (according to Berlin criteria).
See this image and copyright information in PMC

References

    1. Caméléna F, Moy A-C, Dudoignon E, Poncin T, Deniau B, Guillemet L, et al. Performance of a multiplex polymerase chain reaction panel for identifying bacterial pathogens causing pneumonia in critically ill patients with COVID-19. Diagn Microbiol Infect Dis. 2020;99 doi: 10.1016/j.diagmicrobio.2020.115183. - DOI - PMC - PubMed
    1. Ginocchio CC, Garcia-Mondragon C, Mauerhofer B, Rindlisbacher C, EME Evaluation Program Collaborative Multinational evaluation of the BioFire FilmArray Pneumonia plus Panel as compared to standard of care testing. Eur J Clin Microbiol Infect Dis. 2021;40:1609–1622. doi: 10.1007/s10096-021-04195-5. - DOI - PMC - PubMed
    1. Furukawa D, Kim B, Jeng A. Real-life utilization of BioFire Filmarray pneumonia panel as an antibiotic stewardship tool. Infect Dis (Lond) 2021;53:308–313. doi: 10.1080/23744235.2020.1866774. - DOI - PubMed
    1. Maataoui N, Chemali L, Patrier J, Tran Dinh A, Le Fèvre L, Lortat-Jacob B, et al. Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit. Eur J Clin Microbiol Infect Dis. 2021 - PMC - PubMed
    1. Mitton B, Rule R, Said M. Laboratory evaluation of the BioFire FilmArray Pneumonia plus panel compared to conventional methods for the identification of bacteria in lower respiratory tract specimens: a prospective cross-sectional study from South Africa. Diagn Microbiol Infect Dis. 2021;99 doi: 10.1016/j.diagmicrobio.2020.115236. - DOI - PMC - PubMed

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