THE ROLE OF INSULIN-LIKE GROWTH FACTOR-1 AND INSULIN IN DEVELOPMENT OF COLORECTAL CANCER

Abstract

The study's goal is to discover the function of the IGF-1 factor and insulin in the development of colorectal cancer. Changes in these factors should be explored at various phases of colorectal cancer, including the preoperative and postoperative periods. 38 patients were selected for the study. Patients were divided into two groups: the first group - patients with colorectal cancer, and the second group - practically healthy. The first group included 27 patients with colorectal cancer. The second group included 11 practically healthy patients, who ranged in age from 45 to 65. The patients underwent physical and clinical-laboratory examinations: IGF-1 laboratory test: determination of IGF binding-protein 3 and Insulin levels. The study showed that the levels of IGF-1 and insulin increased significantly in patients with colorectal cancer, while the level of IGF binding-protein 3 decreased sharply. The difference between preoperative and postoperative biomarkers was negligible. According to our findings, an increase in insulin and IGF-1 levels, as well as a substantial reduction in IGF binding-protein 3 levels, may play a role in the development of colorectal cancer, although their alterations do not vary significantly in the first three phases of disease progression. It should be noted that these indices decreased in the fourth stage.