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. 2022 Mar;37(2):1289-1297.
doi: 10.1007/s10103-021-03387-x. Epub 2021 Aug 8.

Effect of extracorporeal shock waves on inflammation and angiogenesis of integumentary tissue in obese individuals: stimulating repair and regeneration

Débora Aparecida Oliveira Modena  1   2 , Ciro Dantas Soares  3 , Elaine Cristina Candido  4 , Felipe David Mendonça Chaim  4 , Everton Cazzo  4 , Elinton Adami Chaim  4
Affiliations

Effect of extracorporeal shock waves on inflammation and angiogenesis of integumentary tissue in obese individuals: stimulating repair and regeneration

Débora Aparecida Oliveira Modena et al. Lasers Med Sci. 2022 Mar.

Abstract

The technology of extracorporeal shock wave therapy (ESWT) has been studied around the world for its possible benefits in the treatment and rehabilitation of aesthetic disorders. To better elucidate its real physiological effect on the integumentary tissue, this study was proposed aimed at evaluating whether ESWT can act to stimulate the inflammatory process and angiogenesis in the dermis and epidermis of obese individuals. This is an immunohistological study that evaluated a set of samples of the integumentary tissue of women with grade II obesity with weight loss of 10% of the initial weight undergoing ESWT treatment; the collection of biological material was performed at the time of surgery of bariatric surgery. For immunohistochemical evaluation, the markers to assess the presence and distribution of inflammatory cells, anti-COX-2, CD3, CD20, CD163, and NK were used. For physiological stimulus pathways for blood vessel angiogenesis, markers CD 34, CD 105 and VEGF were used. Fourteen obese women were included in the study. Positivity was evidenced in the epidermal expression of markers of the inflammatory process COX-2, CD3, CD20, NK cells, CD68, and CD163 (p < 0.0001) in the intervention sample when compared to controls. There was a positive expression for the angiogenesis markers CD105 and VEGF (p < 0.0001) when comparing the intervention group with the control group. It was concluded that ESWT can stimulate a local inflammatory process, mediating and modulating important growth factors to act in the repair process and skin tissue regeneration, being considered a promising treatment for skin diseases related to weight gain or loss.

Keywords: Angiogenesis; Inflammation; Obesity; Repair and regeneration; Shock waves.

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References

    1. Dąbrowska AK, Spano F, Derler S et al (2018) The relationship between skin function, barrier properties, and body-dependent factors. Skin Res Technol 24(2):165–174 - DOI
    1. Bonté F, Girard D, Archambault JC, Desmoulière A (2019) Skin changes during ageing. Subcell Biochem 91:249–280 - DOI
    1. Greenway FL (2015) Physiological adaptations to weight loss and factor favoring weight regain. Int J Obes 39(8):1188–1196 - DOI
    1. Chooi YC, Ding C, Magkos F (2019) The epidemiology of obesity. Metab, Clin Exp 92:6–10 - DOI
    1. Modena D, da Silva CN, Grecco C, Guidi RM, Moreira RG, Coelho AA, de Souza JR (2017) Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat Systematic review. J Cosmet Laser Ther 19(6):314–319 - DOI

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