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Review
. 2021;101(1-2):31-50.
doi: 10.1007/s10847-021-01097-z. Epub 2021 Aug 3.

Cyclodextrin-based Pickering emulsions: functional properties and drug delivery applications

Mario Jug  1 , Bo Kyeong Yoon  2 , Joshua A Jackman  2
Affiliations
Review

Cyclodextrin-based Pickering emulsions: functional properties and drug delivery applications

Mario Jug et al. J Incl Phenom Macrocycl Chem. 2021.

Abstract

Cyclodextrins (CDs) are biocompatible, cyclic oligosaccharides that are widely used in various industrial applications and have intriguing interfacial science properties. While CD molecules typically have low surface activity, they are capable of stabilizing emulsions by inclusion complexation of oil-phase components at the oil/water interface, which results in Pickering emulsion formation. Such surfactant-free formulations have gained considerable attention in recent years, owing to their enhanced physical stability, improved tolerability, and superior environmental compatibility compared to conventional, surfactant-based emulsions. In this review, we critically describe the latest insights into the molecular mechanisms involved in CD stabilization of Pickering emulsions, including covering practical aspects such as methods to prepare CD-based Pickering emulsions, lipid encapsulation, and relevant stability issues. In addition, the rheological and textural features of CD-based Pickering emulsions are discussed and particular attention is focused on promising examples for drug delivery, cosmetic, and nutraceutical applications. The functionality of currently developed CD-based Pickering emulsions is also summarised, including examples such as antifungal uses, and we close by discussing emerging possibilities to utilize the molecular encapsulation of CD-based emulsions for translational medicine applications in the antiviral and antibacterial spaces.

Keywords: Antifungals; Cyclodextrin; Drug delivery; Lipids; Pickering emulsion; Stability.

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Conflict of interest statement

Conflict of interestThe authors have no conflicts of interest to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
Representative structure of a Pickering emulsion. Depending on the characteristics of the stabilising particles, O/W or W/O type emulsions can be formed. Particles dominantly wetted with the water phase (three-phase angle, θ < 90°) will form O/W type emulsions, while particles dominantly wetted by the oil phase (θ > 90°) will form W/O type emulsions
Fig. 2
Fig. 2
Mechanism of Pickering emulsion stabilisation with CDs: A formation of inclusion complexes at the O/W interface at low CD concentration and/or early stages of formation; B crystallisation of oil/CD complexes at the O/W interface occurring at high CD concentration and/or longer interaction time; and C emulsion stabilisation with CD/PEG hydrogel
See this image and copyright information in PMC

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References

    1. Albert C, Beladjine M, Tsapis N, Fattal E, Agnely F, Huang N. Pickering emulsions: preparation processes, key parameters governing their properties and potential for pharmaceutical applications. J. Control Release. 2019;309:302–332. doi: 10.1016/j.jconrel.2019.07.003. - DOI - PubMed
    1. Tai Z, Huang Y, Zhu Q, Wu W, Yi T, Chen Z, Lu Y. Utility of Pickering emulsions in improved oral drug delivery. Drug Discov Today. 2020;25:2038–2045. doi: 10.1016/j.drudis.2020.09.012. - DOI - PubMed
    1. Lémery E, Briançon S, Chevalier Y, Bordes C, Oddos T, Gohier A, Bolzinger MA. Skin toxicity of surfactants: structure/toxicity relationships. Colloids. Surf A. Physicochem. Eng. Asp. 2015;469:166–179. doi: 10.1016/j.colsurfa.2015.01.019. - DOI
    1. Seweryn A. Interactions between surfactants and the skin – theory and practice. Adv. Colloid. Interface Sci. 2018;256:242–255. doi: 10.1016/j.cis.2018.04.002. - DOI - PubMed
    1. Söderberg L, Engblom J, Lanbeck P, Wahlgren M. Do surface active parenteral formulations cause inflammation? Int. J. Pharm. 2015;484:246–251. doi: 10.1016/j.ijpharm.2015.02.045. - DOI - PubMed

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