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Review
. 2021 Jul 21:12:707330.
doi: 10.3389/fmicb.2021.707330. eCollection 2021.

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Ekaterina Avershina  1   2 , Valeria Shapovalova  3 , German Shipulin  3
Affiliations
Review

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

Ekaterina Avershina et al. Front Microbiol. .

Abstract

Rising antibiotic resistance is a global threat that is projected to cause more deaths than all cancers combined by 2050. In this review, we set to summarize the current state of antibiotic resistance, and to give an overview of the emerging technologies aimed to escape the pre-antibiotic era recurrence. We conducted a comprehensive literature survey of >150 original research and review articles indexed in the Web of Science using "antimicrobial resistance," "diagnostics," "therapeutics," "disinfection," "nosocomial infections," "ESKAPE pathogens" as key words. We discuss the impact of nosocomial infections on the spread of multi-drug resistant bacteria, give an overview over existing and developing strategies for faster diagnostics of infectious diseases, review current and novel approaches in therapy of infectious diseases, and finally discuss strategies for hospital disinfection to prevent MDR bacteria spread.

Keywords: ESKAPE pathogens; antimicrobial resistance; disease prevention; fast diagnostics; therapeutics.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Drug Resistance Index worldwide. Only countries that reported data on antibiotic use for ≥5 pathogens and for ≥15 pathogen–antibiotic combinations for at least 1 year between 2012 and 2015 are depicted. Data taken from Klein et al. (2019). Data on Taiwan are taken from Resistance Map (https://resistancemap.cddep.org).
See this image and copyright information in PMC

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