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Review
. 2021 Jul 26;13(7):753-775.
doi: 10.4252/wjsc.v13.i7.753.

Stem cell therapies in tendon-bone healing

Yue Xu  1 , Wan-Xia Zhang  1 , Li-Na Wang  1 , Yue-Qing Ming  1 , Yu-Lin Li  1 , Guo-Xin Ni  2
Affiliations
Review

Stem cell therapies in tendon-bone healing

Yue Xu et al. World J Stem Cells. .

Abstract

Tendon-bone insertion injuries such as rotator cuff and anterior cruciate ligament injuries are currently highly common and severe. The key method of treating this kind of injury is the reconstruction operation. The success of this reconstructive process depends on the ability of the graft to incorporate into the bone. Recently, there has been substantial discussion about how to enhance the integration of tendon and bone through biological methods. Stem cells like bone marrow mesenchymal stem cells (MSCs), tendon stem/progenitor cells, synovium-derived MSCs, adipose-derived stem cells, or periosteum-derived periosteal stem cells can self-regenerate and potentially differentiate into different cell types, which have been widely used in tissue repair and regeneration. Thus, we concentrate in this review on the current circumstances of tendon-bone healing using stem cell therapy.

Keywords: Anterior cruciate ligament; Bone; Rotator cuff; Stem cell; Tendon.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflict of interests for this article.

Figures

Figure 1
Figure 1
Structure of the tendon-bone insertion. Zone I consists of ligament. Zone II comprises nonmineralized fibrocartilage. Zone III is composed mineralized cartilage. Zone IV consists of bone. Tidemark between Zone II and Zone III (black arrow) is shown.
See this image and copyright information in PMC

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