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Case Reports
. 2021 Jul 23:9:2050313X211034351.
doi: 10.1177/2050313X211034351. eCollection 2021.

A case of parasympathetic hyperactivity and associated Parry-Romberg syndrome

Andrea N Clapp  1 , Anna DePold Hohler  1   2
Affiliations
Case Reports

A case of parasympathetic hyperactivity and associated Parry-Romberg syndrome

Andrea N Clapp et al. SAGE Open Med Case Rep. .

Abstract

This case report describes a 46-year-old female with a history of multiple endocrine neoplasia type 1 syndrome status post-parathyroidectomy, thymectomy via robotic video-assisted thoracoscopic surgery, and pituitary adenoma resection presenting with parasympathetic hyperactivity and Parry-Romberg syndrome. Parry-Romberg syndrome is a rare disorder that manifests as facial hemiatrophy. Reported symptoms include cognitive dysfunction, olfactory hallucinations, and parasympathetic hyperactivity: miosis of the right eye, anhidrosis, diarrhea, urinary incontinence, bowel incontinence, and orthostatic hypotension. Previous reports have noted associations between Parry-Romberg syndrome and sympathetic hyperactivity and dysregulation. This case report focuses on an association between Parry-Romberg syndrome and unopposed parasympathetic activity.

Keywords: Parry–Romberg syndrome; autonomic dysfunction; dysautonomia; hemifacial atrophy; parasympathetic hyperactivity.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Right-sided facial atrophy of the cheek and nose.
Figure 2.
Figure 2.
Coup de sabre noted on the forehead.
See this image and copyright information in PMC

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