Induction Strategy for Locally Advanced Thymoma
- PMID: 34367988
- PMCID: PMC8339962
- DOI: 10.3389/fonc.2021.704220
Induction Strategy for Locally Advanced Thymoma
Abstract
Surgery remains cornerstone for the management of thymoma. Complete surgical resection (R0), is recognized as the constant and significant factor for prognosis. However, in locally advanced (Masaoka-Koga stages III-IVa) thymomas, achieving R0 resection remains challenging due to local-regional invasion of the disease. Induction treatment, with the aim of reducing bulky tumor mass, offers new strategy to facilitate totally surgical resection. Herein, we reviewed recent progress and provided a comprehensive overview of induction strategy in locally advance thymoma.
Keywords: R0 resection; induction therapy; locally advanced; neoadjuvant; thymoma.
Copyright © 2021 Zhang, Li, Chen, Tan, Zeng, Ding and Du.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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References
-
- Roden AC, Yi ES, Jenkins SM, Edwards KK, Donovan JL, Cassivi SD, et al. . Modified Masaoka Stage and Size Are Independent Prognostic Predictors in Thymoma and Modified Masaoka Stage Is Superior to Histopathologic Classifications. J Thorac Oncol (2015) 10:691–700. 10.1097/JTO.0000000000000482 - DOI - PubMed
-
- Huang J, Ahmad U, Antonicelli A, Catlin AC, Fang W, Gomez D, et al. . Development of the International Thymic Malignancy Interest Group International Database: An Unprecedented Resource for the Study of a Rare Group of Tumors. J Thorac Oncol (2014) 9:1573–8. 10.1097/JTO.0000000000000269 - DOI - PubMed
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