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Review
. 2021 Jul 22:11:704220.
doi: 10.3389/fonc.2021.704220. eCollection 2021.

Induction Strategy for Locally Advanced Thymoma

Yang Zhang  1 , Zongjuan Li  1 , Yixing Chen  1 , Lijie Tan  2 , Zhaochong Zeng  1 , Jianyong Ding  2 , Shisuo Du  1
Affiliations
Review

Induction Strategy for Locally Advanced Thymoma

Yang Zhang et al. Front Oncol. .

Abstract

Surgery remains cornerstone for the management of thymoma. Complete surgical resection (R0), is recognized as the constant and significant factor for prognosis. However, in locally advanced (Masaoka-Koga stages III-IVa) thymomas, achieving R0 resection remains challenging due to local-regional invasion of the disease. Induction treatment, with the aim of reducing bulky tumor mass, offers new strategy to facilitate totally surgical resection. Herein, we reviewed recent progress and provided a comprehensive overview of induction strategy in locally advance thymoma.

Keywords: R0 resection; induction therapy; locally advanced; neoadjuvant; thymoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Moser B, Scharitzer M, Hacker S, Ankersmit J, Matilla JR, Lang G, et al. . Thymomas and Thymic Carcinomas: Prognostic Factors and Multimodal Management. Thorac Cardiovasc Surg (2014) 62:153–60. 10.1055/s-0032-1322611 - DOI - PubMed
    1. Roden AC, Yi ES, Jenkins SM, Edwards KK, Donovan JL, Cassivi SD, et al. . Modified Masaoka Stage and Size Are Independent Prognostic Predictors in Thymoma and Modified Masaoka Stage Is Superior to Histopathologic Classifications. J Thorac Oncol (2015) 10:691–700. 10.1097/JTO.0000000000000482 - DOI - PubMed
    1. Khorfan R, Bharat A, Odell DD. Management and Long-Term Outcomes of Advanced Stage Thymoma in the United States. Ann Thorac Surg (2020) 111:223–30. 10.1016/j.athoracsur.2020.05.088 - DOI - PMC - PubMed
    1. Detterbeck FC, Parsons AM. Thymic Tumors. Ann Thorac Surg (2004) 77:1860–9. 10.1016/j.athoracsur.2003.10.001 - DOI - PubMed
    1. Huang J, Ahmad U, Antonicelli A, Catlin AC, Fang W, Gomez D, et al. . Development of the International Thymic Malignancy Interest Group International Database: An Unprecedented Resource for the Study of a Rare Group of Tumors. J Thorac Oncol (2014) 9:1573–8. 10.1097/JTO.0000000000000269 - DOI - PubMed

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