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Review
. 2021 Jul 29:2021:4672959.
doi: 10.1155/2021/4672959. eCollection 2021.

Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control

Marius Nicolae Popescu  1 , Mădălina Gabriela Iliescu  2 , Cristina Beiu  3 , Liliana Gabriela Popa  3 , Mara Mădălina Mihai  3 , Mihai Berteanu  1 , Anca Mirela Ionescu  4
Affiliations
Review

Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control

Marius Nicolae Popescu et al. Biomed Res Int. .

Abstract

Platelet-rich plasma (PRP) has emerged as a significant regenerative therapy used alone or combined mainly with stem cells, autologous fat grafts, hyaluronic acid, and biomaterials in a variety of medical fields, especially in hair regrowth, wound healing, and sports and rehabilitation medicine. However, the results obtained with this biologic therapy are heterogeneous and conflicting. The observed disparities in the effectiveness of PRP therapies may be due to a lack of standardization in blood processing and preparation. This article is aimed at reviewing the main biological parameters that need to be documented for a thorough reporting of quantitative and qualitative characteristics of the PRP injected, to allow a comparison between the quality of samples and the clinically obtained results and advance the efforts towards treatment standardization.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Biological parameters that need to be evaluated for a proper analysis of the platelet-rich plasma (PRP) preparations.
See this image and copyright information in PMC

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