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. 2021 Sep;18(9):e2100458.
doi: 10.1002/cbdv.202100458. Epub 2021 Aug 9.

Neolignans and Sesquiterpenoid from Piper yunnanense

Yu-Xi Chen  1 , Yun-Xia You  1 , Li Rao  1 , Yu Liu  1 , Qian He  1 , You-Kai Xu  2 , Bin Lin  3 , Chuan-Rui Zhang  1   4
Affiliations

Neolignans and Sesquiterpenoid from Piper yunnanense

Yu-Xi Chen et al. Chem Biodivers. 2021 Sep.

Abstract

Two biphenyl-type neolignans with a rare dibenzofuran skeleton, including a new one piyunneolignan A (1) and a known one piperneolignan D (2), together with a new sesquiterpenoid piyunin A (3), were isolated from the leaves and twigs of Piper yunnanense. Their structures were established on the basis of comprehensive spectroscopic data analysis and electronic circular dichroism (ECD) calculation. Piyunneolignan A (1) featured a rare C-2-C-2'/C-3-O-C-3' linkage. Compounds 1-3 were evaluated for their antimicrobial and cytotoxic activities against a panel of bacteria, fungi, and human cancer cell lines, respectively.

Keywords: ECD calculation; Piper yunnanense; dibenzofuran skeleton; neolignans; sesquiterpenoid.

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