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Comparative Study
. 2021 Sep 13;62(5):861-867.
doi: 10.1093/jrr/rrab069.

Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

Takahiro Kataoka  1 , Hina Shuto  1 , Shota Naoe  1 , Junki Yano  1 , Norie Kanzaki  2 , Akihiro Sakoda  2 , Hiroshi Tanaka  2 , Katsumi Hanamoto  1 , Fumihiro Mitsunobu  3 , Hiroaki Terato  4 , Kiyonori Yamaoka  1
Affiliations
Comparative Study

Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

Takahiro Kataoka et al. J Radiat Res. .

Abstract

Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20-40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15-60% and 15-45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.

Keywords: 8-oxoguanine DNA glycosylase; Mn-superoxide dismutase (SOD); oxidative DNA damage; radon.

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Figures

Fig. 1
Fig. 1
Changes in 8-OHdG, 8-oxoguanine DNA glycosylase (OGG1), and SOD levels in the brain (n = 6 mice/group). Data are presented as the mean ± standard error of the mean. *P < 0.05 vs Sham, #P < 0.05, ##P < 0.001 vs 1 day (1 d).
Fig. 2
Fig. 2
Changes in 8-OHdG, 8-oxoguanine DNA glycosylase (OGG1), and SOD levels in the kidney (n = 6 mice/group). Data are presented as the mean ± standard error of the mean. *P < 0.05, ***P < 0.001 vs Sham; #P < 0.05 vs 1 day (1 d).
Fig. 3
Fig. 3
Changes 8-OHdG, 8-oxoguanine DNA glycosylase (OGG1), and SOD levels in the small intestine (n = 5–6 mice/group). Data are presented as the mean ± standard error of the mean. *P < 0.05 vs Sham.
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