Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Nov;148(5):1161-1164.
doi: 10.1016/j.jaci.2021.07.034. Epub 2021 Aug 6.

Epithelial dysregulation in chronic rhinosinusitis with nasal polyposis (CRSwNP) and aspirin-exacerbated respiratory disease (AERD)

Michael A Kohanski  1 , Noam A Cohen  1 , Nora A Barrett  2
Affiliations
Editorial

Epithelial dysregulation in chronic rhinosinusitis with nasal polyposis (CRSwNP) and aspirin-exacerbated respiratory disease (AERD)

Michael A Kohanski et al. J Allergy Clin Immunol. 2021 Nov.
No abstract available

Keywords: Nasal polyposis; airway inflammation; asthma; basal cell; chemosensory cell; epithelial cell.

PubMed Disclaimer

Conflict of interest statement

Disclosure of Potential Conflicts of Interest:

Dr. Barrett is a consultant for Regeneron and Biohaven Pharmaceuticals

Dr. Cohen is a consultant for Regeneron, Sanofi, GSK, Novartis, Oyster Point Pharma and has a licensing agreement with GeneOne Life Sciences

Dr. Kohanski has no relevant conflicts of interest.

Figures

Figure 1:
Figure 1:
T2 Cytokine-Dependent Airway Remodeling in Nasal Polyposis. The airway epithelial barrier includes ciliated cells (tan), secretory club and goblet cells (pink), tuft/chemosensory EpCs (blue) and basal EpC progenitors (plum). Under the influence of IL-4 and IL-13, basal cells and tuft cells are expanded, increasing the epithelial potential to generate IL-33, TSLP, IL-25, and CysLTs. Additionally, ALOX15 is induced, which can promote tissue eosinophilia. Diverse immunoregulatory molecules are downregulated by IL-4 and IL-13, and detected at reduced levels in nasal polyp EpCs from CRSwNP and AERD. These include PGE2 and STING.
See this image and copyright information in PMC

References

    1. Kohanski MA, Workman AD, Patel NN, Hung LY, Shtraks JP, Chen B, et al. Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2018;142(2):460–9 e7. - PMC - PubMed
    1. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, et al. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018;560(7720):649–54. - PMC - PubMed
    1. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, et al. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016;137(5):1566–76 e5. - PMC - PubMed
    1. Kristjansson RP, Benonisdottir S, Davidsson OB, Oddsson A, Tragante V, Sigurdsson JK, et al. A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. Nat Genet. 2019;51(2):267–76. - PubMed
    1. Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, et al. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020;5(43). - PMC - PubMed

Publication types