Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 2;13(7):1299.
doi: 10.3390/v13071299.

Spatial Distribution and Burden of Emerging Arboviruses in French Guiana

Sarah Bailly  1 , Dominique Rousset  2 , Camille Fritzell  1 , Nathanaël Hozé  3 , Sarrah Ben Achour  2 , Léna Berthelot  2 , Antoine Enfissi  2 , Jessica Vanhomwegen  4 , Henrik Salje  3   5 , Sandrine Fernandes-Pellerin  6 , Mona Saout  1 , Anne Lavergne  2 , Jean-Claude Manuguerra  4 , Jean-François Carod  7 , Félix Djossou  8 , Simon Cauchemez  3 , Claude Flamand  1   3
Affiliations

Spatial Distribution and Burden of Emerging Arboviruses in French Guiana

Sarah Bailly et al. Viruses. .

Abstract

Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6-75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7-23.1), 23.3% (20.9-25.9) and 3.3% (2.7-4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns.

Keywords: Chikungunya; Dengue; French Guiana; Mayaro; Zika; arboviruses; prevalence studies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Map of French Guiana with geographical areas.
Figure 2
Figure 2
Spatial distribution of (a) DENV seroprevalence, (b) CHIKV seroprevalence, (c) ZIKV seroprevalence and (d) MAYV seroprevalence, French Guiana, 2017.
Figure 3
Figure 3
Sample distribution of arboviruses infections and co-infections.
Figure 4
Figure 4
Graphical representation of the correlations between DENV, CHIKV and ZIKV seroprevalences levels; (a) DENV (X) vs. CHIKV (Y); (b) DENV (X) vs. ZIKV (Y); (c) CHIKV (X) vs. ZIKV seroprevalence (Y).
See this image and copyright information in PMC

References

    1. Gould E., Pettersson J., Higgs S., Charrel R., De Lamballerie X. Emerging arboviruses: Why today? One Health. 2017;4:1–13. doi: 10.1016/j.onehlt.2017.06.001. - DOI - PMC - PubMed
    1. Gould E., Coutard B., Malet H., Morin B., Jamal S., Weaver S., Gorbalenya A., Moureau G., Baronti C., Delogu I., et al. Understanding the alphaviruses: Recent research on important emerging pathogens and progress towards their control. Antivir. Res. 2010;87:111–124. doi: 10.1016/j.antiviral.2009.07.007. - DOI - PMC - PubMed
    1. Pettersson J.H.-O., Eldholm V., Seligman S.J., Lundkvist Å., Falconar A.K., Gaunt M.W., Musso D., Nougairède A., Charrel R., Gould E.A., et al. How Did Zika Virus Emerge in the Pacific Islands and Latin America? MBio. 2016;7:e01239-16. doi: 10.1128/mBio.01239-16. - DOI - PMC - PubMed
    1. Bhatt S., Gething P.W., Brady O.J., Messina J.P., Farlow A.W., Moyes C.L., Drake J.M., Brownstein J.S., Hoen A.G., Sankoh O., et al. The global distribution and burden of dengue. Nat. Cell Biol. 2013;496:504–507. doi: 10.1038/nature12060. - DOI - PMC - PubMed
    1. Kraemer M.U.G., Reiner R.C., Brady O.J., Messina J.P., Gilbert M., Pigott D.M., Yi D., Johnson K., Earl L., Marczak L.B., et al. Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus. Nat. Microbiol. 2019;4:854–863. doi: 10.1038/s41564-019-0376-y. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources