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Review
. 2021 Sep;14(3):429-441.
doi: 10.1016/j.path.2021.05.007.

Molecular Approach to Colorectal Carcinoma: Current Evidence and Clinical Application

Cameron Beech  1 , Jaclyn F Hechtman  2
Affiliations
Review

Molecular Approach to Colorectal Carcinoma: Current Evidence and Clinical Application

Cameron Beech et al. Surg Pathol Clin. 2021 Sep.

Abstract

Colorectal carcinoma is one of the most common cancer types in men and women, responsible for both the third highest incidence of new cancer cases and the third highest cause of cancer deaths. In the last several decades, the molecular mechanisms surrounding colorectal carcinoma's tumorigenesis have become clearer through research, providing new avenues for diagnostic testing and novel approaches to therapeutics. Laboratories are tasked with providing the most current information to help guide clinical decisions. In this review, we summarize the current knowledge surrounding colorectal carcinoma tumorigenesis and highlight clinically relevant molecular testing.

Keywords: Colorectal carcinoma; Epidermal growth factor receptor; Immunotherapy; Lynch syndrome; Microsatellite instability.

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