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. 2021 Aug;9(1):e002385.
doi: 10.1136/bmjdrc-2021-002385.

Iron parameters in patients with partial lipodystrophy and impact of exogenous leptin therapy

Efe Y Akinci  1 , Sabine Boutros  1 , Benjamin J Ryan  2 , Pinar Sargin  1 , Baris Akinci  1 , Adam H Neidert  1 , Rita Hench  1 , Jeffrey F Horowitz  2 , Elif A Oral  3
Affiliations

Iron parameters in patients with partial lipodystrophy and impact of exogenous leptin therapy

Efe Y Akinci et al. BMJ Open Diabetes Res Care. 2021 Aug.
No abstract available

Keywords: leptin.

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Conflict of interest statement

Competing interests: EAO reports the following conflicts: grant support: Aegerion Pharmaceuticals (now Amryt Pharmaceuticals), Ionis Pharmaceuticals, Akcea Therapeutics, Gemphire Therapeutics, GI Dynamics (current), AstraZeneca (past 2 years); consultant or advisor: AstraZeneca, Thera Therapeutics, and BMS (past), Aegerion Pharmaceuticals (now Amryt Pharmaceuticals), Regeneron Pharmaceuticals (current); drug support: Aegerion Pharmaceuticals (now Amryt Pharmaceuticals), Akcea Therapeutics, Rhythm Pharmaceuticals (all current); other support: Aegerion Pharmaceuticals (now Amryt Pharmaceuticals), Regeneron Pharmaceuticals (current). BA has attended Scientific Advisory Board Meetings organized by Aegerion Pharmaceuticals (now Amryt Pharmaceuticals) and Regeneron Pharmaceuticals and has received honoraria as a speaker from AstraZeneca, Lilly, MSD, Novartis, Novo Nordisk, Boehringer-Ingelheim, Servier, and Sanofi-Aventis. Other authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Correlation of ferritin with fasting glucose (A) and HbA1c (B). The effect of exogenous leptin on ferritin (C), iron (D), hepcidin (E) and hs-CRP (F). Data are presented as median, IQR. We report the F-statistic and p value from a repeated-measures ANOVA. * indicates p<0.05 versus baseline, paired sample t-test. These p values are marked if they are significant after multiplicity correction. Paired t-test was used to compare month 6 values with baseline (without multiplicity correction) as the change at 6 months versus baseline was a prespecified endpoint. P values were calculated by using log-transformed ferritin, iron, hepcidin and hs-CRP levels. ANOVA, analysis of variance; hs-CRP, high-sensitive C reactive protein.
See this image and copyright information in PMC

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