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. 2021 Jul-Aug;118(4):352-357.

The Deductive Reasoning Strategy Enables Biomedical Breakthroughs

Gina L C Yosten  1 , Grant R Kolar  2 , Daniela Salvemini  1 , Willis K Samson  1
Affiliations

The Deductive Reasoning Strategy Enables Biomedical Breakthroughs

Gina L C Yosten et al. Mo Med. 2021 Jul-Aug.

Abstract

G protein-coupled receptors (GPCRs) transmit the signals of a variety of hormones and neurotransmitters and are targets of more than 30% of all FDA-approved drugs. We developed an approach for identifying the endogenous ligands for a family of orphan GPCRs that enables the development of novel therapeutics for the potential treatment of a wide variety of disorders including pain, diabetes, appetitive behaviors, infertility and obesity. With this approach, we have deorphanized five previously orphaned GPCRs.

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Figures

Figure 1
Figure 1
The Deductive Reasoning Strategy for the G protein-coupled receptor (GPCR) De-Orphanization. Demonstrated here is the identification of a top receptor candidate for neuronostatin (NST) a recently discovered, endogenous hormone,5 that is encoded in the same gene product as somatostatin (SRIF).
None
See this image and copyright information in PMC

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