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Review
. 2021 Jul 30:2021:9599608.
doi: 10.1155/2021/9599608. eCollection 2021.

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy

Armita Mahdavi Gorabi #  1 , Nasim Kiaie #  1 , Saeed Aslani  2 , Thozhukat Sathyapalan  3 , Tannaz Jamialahmadi  4   5 , Amirhossein Sahebkar  6   7   8
Affiliations
Review

Implications on the Therapeutic Potential of Statins via Modulation of Autophagy

Armita Mahdavi Gorabi et al. Oxid Med Cell Longev. .

Abstract

Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attributed to statins, including neuroprotection, antioxidation, anti-inflammation, and anticancer effects. Pharmacological characteristics of statins have been attributed to their involvement in the modulation of several cellular signaling pathways. Over the past few years, the therapeutic role of statins has partially been attributed to the induction of autophagy, which is critical in maintaining cellular homeostasis and accounts for the removal of unfavorable cells or specific organelles within cells. Dysregulated mechanisms of the autophagy pathway have been attributed to the etiopathogenesis of various disorders, including neurodegenerative disorders, malignancies, infections, and even aging. Autophagy functions as a double-edged sword during tumor metastasis. On the one hand, it plays a role in inhibiting metastasis through restricting necrosis of tumor cells, suppressing the infiltration of the inflammatory cell to the tumor niche, and generating the release of mediators that induce potent immune responses against tumor cells. On the other hand, autophagy has also been associated with promoting tumor metastasis. Several anticancer medications which are aimed at inducing autophagy in the tumor cells are related to statins. This review article discusses the implications of statins in the induction of autophagy and, hence, the treatment of various disorders.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Mechanisms by which statins promote autophagy.
See this image and copyright information in PMC

References

    1. Noguchi M., Hirata N., Tanaka T., Suizu F., Nakajima H., Chiorini J. A. Autophagy as a modulator of cell death machinery. Cell Death & Disease. 2020;11(7):512–517. doi: 10.1038/s41419-020-2724-5. - DOI - PMC - PubMed
    1. Tanida I., Ueno T., Kominami E. Autophagosome and phagosome. Springer; 2008. LC3 and autophagy; pp. 77–88. - PubMed
    1. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132(1):27–42. doi: 10.1016/j.cell.2007.12.018. - DOI - PMC - PubMed
    1. Rabinowitz J. D., White E. Autophagy and metabolism. Science. 2010;330(6009):1344–1348. doi: 10.1126/science.1193497. - DOI - PMC - PubMed
    1. Gudipaty S. A., Conner C. M., Rosenblatt J., Montell D. J. Unconventional ways to live and die: cell death and survival in development, homeostasis, and disease. Annual Review of Cell and Developmental Biology. 2018;34:311–332. doi: 10.1146/annurev-cellbio-100616-060748. - DOI - PMC - PubMed

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