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Case Reports
. 2021 Sep;12(18):2517-2520.
doi: 10.1111/1759-7714.14107. Epub 2021 Aug 10.

Low-grade fibromyxoid sarcoma arising from the lung: A case report

Ryuichi Yoshimura  1 , Masao Nishiya  2 , Naoki Yanagawa  2 , Hiroyuki Deguchi  1 , Makoto Tomoyasu  1 , Satoshi Kudo  1 , Wataru Shigeeda  1 , Yuka Kaneko  1 , Hironaga Kanno  1 , Mayu Sugai  2 , Shunsuke Shikanai  2 , Tamotsu Sugai  2 , Hajime Saito  1
Affiliations
Case Reports

Low-grade fibromyxoid sarcoma arising from the lung: A case report

Ryuichi Yoshimura et al. Thorac Cancer. 2021 Sep.

Abstract

Low-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma subtype that most commonly arises in young adults. This tumor typically presents in the deep soft tissues of the proximal extremities or trunk as a painless mass. Although the most common site of LGFMS metastasis is the lung, it is rarely the primary site. Here, we report a case of primary pulmonary LGFMS. A 22-year-old asymptomatic man was referred to our hospital for investigation of a lung mass that had been discovered incidentally. Computed tomography (CT) showed a well-defined mass 4.0 cm in diameter in the upper lobe of the right lung. Malignancy was suggested by focal uptake of 18F-fluorodeoxyglucose positron-emission tomography (18-FDG-PET). Following surgery, postoperative histological analysis of the resected specimen demonstrated LGFMS based on histological and immunohistological findings. In particular, mucin 4 showed diffuse positivity in the spindle-shaped tumor cells. In conclusion, LGFMS can arise in the lungs, and physicians should consider this entity as a differential diagnosis for solitary lung mass in young adults.

Keywords: Evans tumor; low-grade fibromyxoid sarcoma; lung tumor.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Chest X‐ray findings. (a) No shadows had been detected on simple chest X‐ray 1.5 years previously. (b) Chest X‐ray indicated a smooth, mass shadow in the right upper lung
FIGURE 2
FIGURE 2
Preoperative imaging. (a) Computed tomography (CT) indicated a solid mass with peripheral atelectasis in the right upper lobe. (b) 18‐fluorodeoxyglucose (18‐FDG)‐positron emission tomography (PET) showed focal FDG uptake, with a maximum standardized uptake value of 5.59 in the mass
FIGURE 3
FIGURE 3
(a) Divided surface of the tumor showed a tan‐whitish, homogeneous, solid tumor. (b) Histological examination showed spindle‐shaped cells in a myxoid and fibrous matrix. (c) The rosettes were composed of a core of mature collagen surrounded by epithelioid cell. (d) Diffuse MUC4 positivity was seen in the tumor cells
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