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. 2022 May;19(4):734-740.
doi: 10.1111/iwj.13669. Epub 2021 Aug 10.

Measuring progress to healing: A challenge and an opportunity

Richard Hillson Bull  1 , Karen Louise Staines  2 , Agnes Juguilon Collarte  3 , Duncan Shirreffs Bain  4 , Nicola M Ivins  5 , Keith Gordon Harding  6
Affiliations

Measuring progress to healing: A challenge and an opportunity

Richard Hillson Bull et al. Int Wound J. 2022 May.

Abstract

Complete healing is problematic as an endpoint for evaluating interventions for wound healing. The great heterogeneity of wounds makes it difficult to match groups, and this is only possible with multivariate stratification and/or very large numbers of subjects. The substantial time taken for wounds to heal necessitates a very lengthy study. Consequently, high quality randomised controlled trials demonstrating an effect of an intervention to a satisfactory level of statistical significance and with a satisfactory level of generalisability are extremely rare. This study determines that the healing of venous leg ulcers receiving multi-component compression bandaging follows a linear trajectory over a 4-week period, as measured by gross area healed, percentage area healed, and advance of the wound margin. The linear trajectories of these surrogates make it possible to identify an acceleration in healing resulting from an intervention, and allows self-controlled or crossover designs with attendant advantages of statistical power and speed. Of the metrics investigated, wound margin advance was the most linear, and was also independent of initial ulcer size.

Keywords: intermediate measure; surrogate; venous leg ulcer; wound margin advance.

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Figures

FIGURE 1
FIGURE 1
Healing trajectory of two theoretical wounds A and B
FIGURE 2
FIGURE 2
Gross area reduction relative to start (n = 40), ±SE
FIGURE 3
FIGURE 3
Percentage area reduction relative to start (n = 40), ±SE
FIGURE 4
FIGURE 4
Wound margin advance relative to start (n = 40), ±SE
See this image and copyright information in PMC

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