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. 2021 Oct 1;204(7):855-856.
doi: 10.1164/rccm.202011-4182IM.

In Vivo Thrombosis Imaging in Patients Recovering from COVID-19 and Pulmonary Embolism

Rong Bing  1 , Jack P M Andrews  1 , Michelle C Williams  1   2 , Edwin J R van Beek  2 , Christophe Lucatelli  2 , Gillian MacNaught  2 , Tim Clark  2 , Norman Koglin  3 , Andrew W Stephens  3 , Mark G MacAskill  1 , Adriana A S Tavares  1 , Kevin Dhaliwal  4 , David A Dorward  4 , Christopher D Lucas  4 , Marc R Dweck  1 , David E Newby  1   2
Affiliations

In Vivo Thrombosis Imaging in Patients Recovering from COVID-19 and Pulmonary Embolism

Rong Bing et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) The left shows segmental pulmonary embolus with associated 18F-GP1 uptake, and the right shows focal 18F-GP1 uptake without computed tomography pulmonary angiogram evidence of subsegmental thrombus. (B) Three examples of parenchymal 18F-GP1 uptake associated with consolidation (left), healing peripheral infarction (middle), and nodular uptake in ground-glass changes with an associated dilated pulmonary artery but no evidence of pulmonary embolism at this site on computed tomography pulmonary angiogram (right). (C) Incidental systemic intravascular thrombosis and associated 18F-GP1 uptake at the site of an occluded saphenous vein coronary artery bypass graft (left), apical left ventricular thrombus (middle), and left common femoral vein deep vein thrombosis (right). (D) Hematoxylin and eosin–stained sections of postmortem pulmonary tissue with corresponding 18F-GP1 autoradiography in two patients who died of coronavirus disease (COVID-19). Diffuse alveolar damage and microvascular thrombosis was seen on histopathology. 18F-GP1 colocalizes to intravascular thrombus (left, center-left) but not to more organized thrombus of older duration (center-right, right). There is also 18F-GP1 signal in smoking-related anthracotic pigment.
See this image and copyright information in PMC

References

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