Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Aug 9;56(15):2142-2144.
doi: 10.1016/j.devcel.2021.07.007.

Distributed and centralized control during differentiation

Jonathan R Chubb  1 , Hugh Z Ford  2 , Vlatka Antolović  2
Affiliations
Free article
Comment

Distributed and centralized control during differentiation

Jonathan R Chubb et al. Dev Cell. .
Free article

Abstract

A persistent view of cell fate choices during development entails centralized control by so-called master regulators. A recent single-cell study of the large-scale fate specification during mammalian gastrulation (Mittnenzweig et al., 2021) implies the prevalence of more distributed forms of control.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • A single-embryo, single-cell time-resolved model for mouse gastrulation.
    Mittnenzweig M, Mayshar Y, Cheng S, Ben-Yair R, Hadas R, Rais Y, Chomsky E, Reines N, Uzonyi A, Lumerman L, Lifshitz A, Mukamel Z, Orenbuch AH, Tanay A, Stelzer Y. Mittnenzweig M, et al. Cell. 2021 May 27;184(11):2825-2842.e22. doi: 10.1016/j.cell.2021.04.004. Epub 2021 Apr 30. Cell. 2021. PMID: 33932341 Free PMC article.

LinkOut - more resources