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Comment
. 2021 Aug 9;39(8):1056-1058.
doi: 10.1016/j.ccell.2021.07.010.

Optic nerve activity promotes the growth of optic pathway gliomas: Shedding light on the glioma microenvironment

Bárbara da Silva  1 , Howard A Fine  2
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Free article
Comment

Optic nerve activity promotes the growth of optic pathway gliomas: Shedding light on the glioma microenvironment

Bárbara da Silva et al. Cancer Cell. .
Free article

Abstract

In a recent issue of Nature, Pan and colleagues explore whether light-induced stimulation of the optic nerve could influence the biology of optic gliomas. This study highlights the importance of neuronal-glioma interactions.

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  • NF1 mutation drives neuronal activity-dependent initiation of optic glioma.
    Pan Y, Hysinger JD, Barron T, Schindler NF, Cobb O, Guo X, Yalçın B, Anastasaki C, Mulinyawe SB, Ponnuswami A, Scheaffer S, Ma Y, Chang KC, Xia X, Toonen JA, Lennon JJ, Gibson EM, Huguenard JR, Liau LM, Goldberg JL, Monje M, Gutmann DH. Pan Y, et al. Nature. 2021 Jun;594(7862):277-282. doi: 10.1038/s41586-021-03580-6. Epub 2021 May 26. Nature. 2021. PMID: 34040258 Free PMC article.

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